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Full-Text Articles in Medicine and Health Sciences
Heparan Sulfate, A New Target For Platinum In Metastatic Tnbc, Samantha J. Katner
Heparan Sulfate, A New Target For Platinum In Metastatic Tnbc, Samantha J. Katner
Theses and Dissertations
Abstract
Heparan Sulfate, A New Target for Platinum in Metastatic TNBC
Author: Samantha J. Katner, Ph.D.
A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy
Virginia Commonwealth University, 2018
Advisor: Dr. Nicholas Farrell, Professor, Chemistry Department
Heparan sulfate proteoglycans (HSPGs), composed of the linear polysaccharide heparan sulfate (HS) conjugated to a protein core, are located on the cell surface and extracellular matrix. The HS chains display varying degrees of sulfation, which constitutes the molecular recognition motif for many HS-protein interactions. HSPGs, associated growth factors, and heparanase promote tumor progression by facilitating invasion, angiogenesis, …
Functionalization And Modification Of Naphthaquinone Analogs As Her2 Kinase Inhibitors, Divya Jyothi Lella
Functionalization And Modification Of Naphthaquinone Analogs As Her2 Kinase Inhibitors, Divya Jyothi Lella
Masters Theses & Specialist Projects
HER2 overexpression in breast cancer tumors predicts lower overall survival. Because of the aggressive nature of HER2 tumors and the association with metastatic disease, the HER2 receptor holds great promise as a therapeutic target in metastatic breast cancer. We are developing small molecule inhibitors that bind to the ATP binding site of the tyrosine kinase domain in order to inhibit tyrosine auto-phosphorylation. This process controls biological pathways that mediate the cell growth. In normal cells this process is highly controlled. We are targeting the modification of the side chain of the hydroxy methyl group of 2-Hydroxy methyl-5,8-dimethoxy-1,4-naphthaquinone. These compounds should …
Is Aspirin Effective In Helping To Prevent Breast Cancer In Women Ages 45 Years And Older?, Kristen M. Quartuccio
Is Aspirin Effective In Helping To Prevent Breast Cancer In Women Ages 45 Years And Older?, Kristen M. Quartuccio
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not aspirin is effective in helping to prevent breast cancer in women ages 45 years and older.
STUDY DESIGN: Review of three English language primary studies published in 2005, 2007, and 2008
DATA SOURCES: Two randomized, double blind, placebo controlled clinical trials and one prospective, population based cohort study comparing aspirin to placebo were found using PubMed and Cochrane databases.
OUTCOMES MEASURED: Breast cancer development was measured in several ways. Tumor characteristics were measured at diagnosis, including size, metastasis to lymph nodes, histology of the mass, histology …
Metastatic Disease: Interactions Between Tumor Cells And Host Environment During Cancer Cell Spread, Jennifer M. Maclean
Metastatic Disease: Interactions Between Tumor Cells And Host Environment During Cancer Cell Spread, Jennifer M. Maclean
Electronic Thesis and Dissertation Repository
Tumor and metastasis formation are not cell autonomous phenomena, but rather an evolution of disease within and responding to the host environment. Metastatic spread from a primary tumor occurs as a result of a complex interplay between tumor cells and the host, wherein tumor cells must escape the primary tumor, enter the host vasculature, travel to and arrest in a distant tissue and survive and grow in that new organ. It is known that cells that progress through these stages must both escape and exploit host systems, yet the mechanisms used are not fully understood. Therefore, the goal of this …
Does Venlafaxine (Effexor) Decrease The Frequency Of Hot Flashes In Women With Breast Cancer?, Allison Berneking
Does Venlafaxine (Effexor) Decrease The Frequency Of Hot Flashes In Women With Breast Cancer?, Allison Berneking
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not “Does venlafaxine (Effexor) decrease the frequency of hot flashes in women with breast cancer?”