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Developing Burrowing As A Non-Evoked Readout Assessment For Novel Analgesic Drug Efficacy, Kayla Lindros, Denise Giuvelis, Ed Bilsky
Developing Burrowing As A Non-Evoked Readout Assessment For Novel Analgesic Drug Efficacy, Kayla Lindros, Denise Giuvelis, Ed Bilsky
Neuroscience Student Research Posters
Traditional drug development efforts to diminish the problem of chronic pain rely heavily on pain-evoked assays that can yield false positives, leading to confounding assessments of novel drugs. To avoid this, we are looking at burrowing as a novel readout assessment of analgesic efficacy. Preliminary data shows that induction of post-surgical pain reduces this innate behavior by about 35%. In attempt to increase this number, we tested a variety of additional parameters. Blue pads, placed at the bottom of each chamber in order to reduce the sound made when gravel is displaced, increased baseline amounts roughly 40%. Conversely, neither sex …