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Full-Text Articles in Medicine and Health Sciences
Detectability Of Excitatory Versus Inhibitory Drive In An Integrate-And-Fire-Or-Burst Thalamocortical Relay Neuron Model, Gregory D. Smith, S. M. Sherman
Detectability Of Excitatory Versus Inhibitory Drive In An Integrate-And-Fire-Or-Burst Thalamocortical Relay Neuron Model, Gregory D. Smith, S. M. Sherman
Arts & Sciences Articles
Although inhibitory inputs are often viewed as equal but opposite to excitatory inputs, excitatory inputs may alter the firing of postsynaptic cells more effectively than inhibitory inputs. This is because spike cancellation produced by an inhibitory input requires coincidence in time, whereas an excitatory input can add spikes with less temporal constraint. To test for such potential differences, especially in the context of the function of thalamocortical (TC) relay nuclei, we used a stochastic “integrate-and-fire-or-burst” TC neuron model to quantify the detectability of excitatory and inhibitory drive in the presence and absence of the low-threshold Ca 2+ current, IT, and …
An Empirical Study Of Marginal Structural Models For Time-Independent Treatment, Tanya A. Henneman, Mark J. Van Der Laan
An Empirical Study Of Marginal Structural Models For Time-Independent Treatment, Tanya A. Henneman, Mark J. Van Der Laan
U.C. Berkeley Division of Biostatistics Working Paper Series
In non-randomized treatment studies a significant problem for statisticians is determining how best to adjust for confounders. Marginal structural models (MSMs) and inverse probability of treatment weighted (IPTW) estimators are useful in analyzing the causal effect of treatment in observational studies. Given an IPTW estimator a doubly robust augmented IPTW (AIPTW) estimator orthogonalizes it resulting in a more e±cient estimator than the IPTW estimator. One purpose of this paper is to make a practical comparison between the IPTW estimator and the doubly robust AIPTW estimator via a series of Monte- Carlo simulations. We also consider the selection of the optimal …