Medicine and Health Sciences Commons^™

Effects Of Dietary Calcium And Fasting On Osteoclast Recession And Recruitment In Calcium Deficient Rats, Kenneth R. Wright

Loma Linda University Electronic Theses, Dissertations & Projects

The osteoclast, a multinucleated giant cell, has as its role the resorption of bone matrix with consequent release of calcium. The osteoclast is thought to derive from a pluripotent stem cell which also gives rise to monocytes and macrophages. The development, activation, and inhibition of osteoclasts are influenced by a number of systemic and local factors. The release of these factors is influenced by changes in the dietary status of the animal. Calcium deficiency is known to stimulate the recruitment and activity of large numbers of osteoclasts. These osteoclasts can subsequently be inhibited by increasing dietary calcium intake. Disappearance of …

Neurophysiologic Bases For Abnormal Muscle Coactivation Patterns In Hemiparetic Stroke, Julius P.A. Dewald

Loma Linda University Electronic Theses, Dissertations & Projects

To study disturbed muscle activation patterns in hemiparetic stroke, the EMG activity in spastic-paretic and contralateral elbow muscles of 10 stroke subjects were compared during graded directionally varying voluntary isometric contractions. We observed significant shifts in the peak EMG angle and increases in the angular range of EMG activity in the impaired upper limb. Furthermore, we observed stereotypic coactivation of many muscles acting at the same joint or at different joints across all subjects.

The effect of elbow angle changes on muscle coactivation patterns was studied by examining isometric torque-angle relations under passive and active conditions in 8 stroke subjects. …

Changes In Intracellular Chloride During Osmotic Stress And L-Alanine Uptake In Mouse Hepatocytes, Kening Wang

Electronic Theses and Dissertations

A stable intracellular ionic environment is necessary for hepatocytes to function normally. Thus, during hypotonic shock or L-alanine uptake, hepatocytes swell and then exhibit a regulatory volume decrease (RVD), which comprises an increase in K$\sp+$ conductance (G$\sb{\rm K}$), an increased K$\sp+$ efflux, and a hyperpolarization of transmembrane potential (V$\sb{\rm m}$). Since hepatocyte intracellular Cl$\sp-$ has been demonstrated to distribute passively with V$\sb{\rm m}$, this study is designed to test the hypothesis that the hypotonic shock- or L-alanine uptake-induced hyperpolarization of V$\sb{\rm m}$ might provide an electromotive force for the efflux of hepatocyte intracellular Cl$\sp-$, which in turn would contribute osmotically …

Red Butte Canyon Research Natural Area: History, Flora, Geology, Climate, And Ecology, James R. Ehleringer, Lois A. Arnow, Ted Arnow, Irving B. Mcnulty, Norman C. Negus

Great Basin Naturalist

Red Butte Canyon is a protected, near pristine canyon entering Salt Lake Valley, Utah. It contains a well-developed riparian zone and a perennial stream; hillside vegetation ranges from grasslands on the lower limits to Douglas-fir and aspen stands at the upper elevations. In this paper we describe the history of human impact, natural history aspects of climate, geology, and ecology, and faunal and floral information for key species in the canyon. The role and importance of Research Natural Areas is discussed, particularly with respect to the need to protect Red Butte Canyon—one of the few remaining undisturbed riparian ecosystems in …

Effects Of Dextro-Methamphetamine On Subjective Fatigue, C. A. Dejohn, Scott Shappell, D. F. Neri

Publications

Declining aircrew performance during periods of sustained flight operations (SUSOPs) has underscored the need to develop effective countermeasures. This paper reports on the ability of the central nervous system (CNS) stimulant d-methamphetamine to alleviate the detrimental effects of a simulated SUSOPs on subjective fatigue. Subjective fatigue was repeatedly measured by three questionnaires. The simulated SUSOP started at 1800 and consisted of a 9-h planning session followed by 4 h of rest and a 14-h mission. After 6 h of sleep, the 9/4/14 work/rest/work pattern was repeated. At 4 1/2 h into the second mission, 13 subjects were administered 10 mg …

The R Value At Vo2 Max During Maximal Graded Exercise Treadmill Tests Of Coronary Artery Diseased And Nondiseased Subjects, Sherry S. Williams

Masters Theses

This study examined the R value at VO2 max during maximal graded treadmill exercise tests to determine if it was a reliable indicator of VO2 max and could therefore be used as a test termination criterion. The subjects in this study were 160 coronary artery diseased (CAD) patients and 170 nondiseased individuals. Data were collected from existing stress test records. The R value was also analyzed to determine if proportions of diseased and nondiseased subjects were the same. The time it took 100 CAD patients to reach VO2 max and exhaustion once R rose above 1.00 was also examined.

The …

Effects Of Strengthening The Stabilizing Muscles Of The Hip Joint On Strength Gain Of The Hamstring Group, Tina M. Wilson

Masters Theses

The problem under investigation was to determine if strengthening the abductor and adductor muscle groups of the hip would increase hamstring flexion strength. Forty females from aerobic classes were put into two groups, control and treatment, after being pretested on the Cybex II Dynamometer. The control group participated only in aerobics, while the treatment group participated in the aerobics and treatment program. The treatment consisted of four exercises working abduction and adduction of the thigh with SPRI's Xercise Band.

After six weeks all subjects were posttested on the Cybex II Dynamometer. Both groups had significant increases in hamstring strength. These …

Plasticity Of The Gnrh Neuronal System During Sexual Maturation Of The Male Djungarian Hamster, Kevin L. Buchanan

Loma Linda University Electronic Theses, Dissertations & Projects

Onset of puberty in male Djungarian hamsters is characterized by increased pituitary gonadotropin secretion and testes maturation, and is controlled by neurons within the brain which secrete gonadotropin-releasing hormone (GnRH). Puberty is associated with increased numbers of morphologically unipolar, but not bipolar, GnRH neurons in the medial preoptic area (MPOA) and diagonal band of Broca (DBB). To test the hypothesis that delayed sexual maturation arrests this increase, males were exposed to short days or administered melatonin. Males with delayed puberty had significantly fewer unipolar GnRH neuron numbers in the MPOA and DBB comparable to pubertal controls in long days. Unipolar …

Dna Extraction From Preserved Trout Tissues, D. K. Shiozawa, J. Kudo, R. P. Evans, S. R. Woodward, R. N. Williams

Great Basin Naturalist

We have adapted techniques developed for the extraction of DNA from formalin-fixed, paraffin-imbedded human tissues for use on preserved fish tissues. DNA was successfully extracted and the d-loop region of mitochondrial DNA was amplified with the polymerase chain reaction (PCR). The sequences of the amplified DNA from preserved and modern samples were identical. These techniques were also applied to fin tissue treated with a variety of preservatives. Extraction of DNA from ethyl alcohol and air-dried fin tissues gave yields equivalent to those from frozen tissues. Extraction of DNA from preserved museum specimens of rare or extinct taxa could significantly increase …

Optimization Of Cryopreservation Protocols For Cardiovascular Tissue, Jianfei Hu

Theses and Dissertations in Biomedical Sciences

The purpose of this research was to determine the effects of cryopreservation on the physical, biochemical and cellular aspects of heart valve tissue. The present study demonstrated that radiolabeled proline accumulation provides a quantitative estimate of total cellular metabolic viability. Radiolabeled inulin was demonstrated to be a useful marker for extracellular tissue space. Assessment of metabolic viability of the cellular population of leaflet tissue as a function of procurement and processing revealed that proline accumulation declined with increasing warm and cold ischemic times. Amphotericin B and streptomycin were toxic to the cells. Cefoxitin, lincomycin, polymyxin B, vancomycin and penicillin had …

Family Physicians, Chiropractors, And Back Pain, Peter Curtis, Geoffrey M. Bove

Biomedical Sciences Faculty Publications

In this article, major aspects of back care provided to patients by family physicians and chiropractors are reviewed, and the recent guidelines on spinal manipulation therapy are discussed. These guidelines should be useful for family physicians wishing to refer patients to chiropractors.

List Of Museum Type Repositories, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Genera Incertae Sedis, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Family Scolytidae, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Addendum, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Family Platypodidae, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Subfamily Coptonotinae, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Introduction (English, French, German, And Spanish), Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Index For Scolytidae, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Hosts Of Scolytidae And Platypodidae, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Subfamily Platypodinae, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Supplement To The 1987 Bibliography, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Subfamily Scolytinae, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Index For Platypodidae, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Subfamily Hylesininae, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Subfamily Tesserocerinae, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Key To Subject Areas, Stephen L. Wood, Donald E. Bright Jr.

Great Basin Naturalist Memoirs

No abstract provided.

Oculomotor Deficits In Diseases Of The Basal Ganglia: Parkinson's And Huntington's Diseases, Todd B. Baird

Theses and Dissertations

Oculomotor deficits are now recognized as being present in several neurological diseases of the basal ganglia. The present report will focus primarily on those observed in Huntington's and Parkinson's diseases. Neuronal cell loss in the pars compacta of the substantia nigra, degeneration of the nigrostriatal pathway, and consequent depletion of the neurotransmitter dopamine is the most obvious etiological abnormality in Parkinson's disease. Huntington's disease, on the other hand, involves the selective genetically-driven atrophy of the striatum (caudate and putamen). In order to attempt to understand oculomotor dysfunction, as a component of basal ganglia disease, it is necessary to first establish …

In Vivo Growth Of C6 Glioma Cells Transfected With Connexin43 Cdna, C. Naus, K. Elisevich, D. Zhu, Daniel Belliveau, R. Del Maestro

Daniel J. Belliveau

In order to examine the possible role of intercellular communication via gap junctions in the control of tumor growth, we have transfected C6 glioma cells with connexin43 cDNA. We obtained several clones with variable expression of connexin43. The growth rate of these clones in culture was inversely related to the degree of expression of the transfected cDNA. To examine the growth of these transfected cells in vivo, cells were grown in spinner culture flasks to form spheroids 250–300 µm in diameter. Spheroids of nontransfected C6 cells produced large gliomas. Immunohistochemical and in situ hybridization analyses revealed relatively high levels of …