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Full-Text Articles in Medicine and Health Sciences
Retrospective Review Of Efficacy Of Repeated Radiofrequency Ablation For Cervical And Lumbosacral Facet Pain, Andrew Carbajal, Robert Mpro, Liz Mortazavi, Casey Murphy
Retrospective Review Of Efficacy Of Repeated Radiofrequency Ablation For Cervical And Lumbosacral Facet Pain, Andrew Carbajal, Robert Mpro, Liz Mortazavi, Casey Murphy
Medical Student Research Poster Symposium
Objectives: Low back pain and neck pain are two very common sources of pain that, without proper treatment, can significantly reduce quality of life and interfere with daily activities.1 It is estimated that up to 84 percent of adults have low back pain at some time in their lives, with 25% of adults reporting low back pain in the last three months.2-4 Additionally, neck pain can often share similar pathology as low back pain, with resultant increasing demand for treatment options. Some studies suggest estimated 1 year incidence of neck pain is between 10.4% and 21.3%,5 with an annual prevalence …
Engineering Self-Assembling Vascular Constructs For A Membrane Free-Microphysiological System, Kevin Conrad, Ethan Byrne, Mark Mondrinos
Engineering Self-Assembling Vascular Constructs For A Membrane Free-Microphysiological System, Kevin Conrad, Ethan Byrne, Mark Mondrinos
Medical Student Research Poster Symposium
Microvasculature mediates the pathophysiology of nearly every disease, and there is an urgent need to better understand how it impacts the initiation, progression, and conclusion of disease. To this end, it is essential to have a reliable method for constructing vascular networks in vitro which phenotypically resemble the human body. Here we optimize the morphology of self- assembling microvascular networks in collagen-fibrin hydrogels for use in a perfusable, membrane-free organ chip (MFOC). Human umbilical vein endothelial cells (HUVEC) and human lung fibroblasts (HLF) were co-cultured in collagen-fibrin hydrogels and vasculogenesis was observed to begin within 24 hours and continue for …
Combination Therapy With Sodium Nitrite And Hydralazine Attenuates Oxidative Stress In Heart Failure With Preserved Ejection Fraction, Kashyap Koul, Kyle Lapenna, Zhen Li, Jake Doiron, John Wang, Thomas E. Sharp Iii, David J. Lefer
Combination Therapy With Sodium Nitrite And Hydralazine Attenuates Oxidative Stress In Heart Failure With Preserved Ejection Fraction, Kashyap Koul, Kyle Lapenna, Zhen Li, Jake Doiron, John Wang, Thomas E. Sharp Iii, David J. Lefer
Medical Student Research Poster Symposium
Introduction: Nitric oxide (NO) based therapeutics are powerful cardioprotective agents in the treatment of heart failure with reduced ejection fraction (HFrEF). However, NO therapy has failed to exert beneficial effects clinical studies of heart failure with preserved ejection fraction (HFpEF), We investigated (1) the effects of the NO donor, sodium nitrite, as a monotherapy, (2) hydralazine monotherapy, a known vasodilator and antioxidant, and (3) combination therapy with both drugs in a murine model of HFpEF assessed of left ventricular (LV) function, exercise tolerance, vascular function and oxidative stress. Methods: Male, C57/BL6N (n=15 per group) were placed on a Western high …
The Onset Of Retinal Degeneration In A Mutation Of Membrane-Type Frizzled-Relatedprotein Oradiponectin Receptor 1 Engages Essential Fatty Acid Impairments, Alise J. Aucoin, Marie Audrey Kautzmann Guerin, William Gordon, Eric Prestenburg, Jeff Ji, Rasangi Perera, Nicolas Bazan
The Onset Of Retinal Degeneration In A Mutation Of Membrane-Type Frizzled-Relatedprotein Oradiponectin Receptor 1 Engages Essential Fatty Acid Impairments, Alise J. Aucoin, Marie Audrey Kautzmann Guerin, William Gordon, Eric Prestenburg, Jeff Ji, Rasangi Perera, Nicolas Bazan
Medical Student Research Poster Symposium
Abnormal lipid metabolism is the derivation of multiple retinal degenerative and blinding diseases. In the LSU Neuroscience Center, the membrane-type frizzled-related protein (MFRP), and adiponectin receptor 1 (AdipoR1) were shown to be vital to the maintenance of a healthy retinal lipidome. The two mice models of retinal degenerations Mfrprd6 and Adipor1 -/- resulted in a reduction of phospholipids containing docosahexaenoic acid (DHA; 22:6) and very long-chain polyunsaturated fatty acids (VLC-PUFAs). In a pathway involving the omega 3 fatty acids eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6), the fatty acid elongase-4 (ELOVL4) elongates the fatty acid 28:6 into VLC-PUFAs, …