Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Animals (29)
- Male (21)
- Female (13)
- Mice (13)
- Humans (12)
-
- Rats (10)
- Aging (7)
- Dopamine (7)
- Inflammation (7)
- Neurons (7)
- Skeletal muscle (7)
- Animal (6)
- Brain (6)
- Gene Expression Regulation (6)
- Mitochondria (6)
- Rats, Sprague-Dawley (6)
- Disease Models (5)
- Disease Models, Animal (5)
- Mice, Inbred C57BL (5)
- Sprague-Dawley (5)
- Adult (4)
- Corpus Striatum (4)
- Middle Aged (4)
- Regeneration (4)
- Signal Transduction (4)
- Age Factors (3)
- Aged (3)
- Amperometry (3)
- Cholesterol (3)
- DENSE (3)
- Publication Year
- Publication
-
- Neuroscience Faculty Publications (38)
- Physiology Faculty Publications (16)
- Internal Medicine Faculty Publications (10)
- Theses and Dissertations--Neuroscience (7)
- Biomedical Engineering Faculty Publications (5)
-
- Center for Muscle Biology Faculty Publications (5)
- Physical Therapy Faculty Publications (5)
- Pharmacology and Nutritional Sciences Faculty Publications (4)
- Theses and Dissertations--Kinesiology and Health Promotion (4)
- Markey Cancer Center Faculty Publications (3)
- Pediatrics Faculty Publications (3)
- Saha Cardiovascular Research Center Faculty Publications (3)
- Theses and Dissertations--Physiology (3)
- University of Kentucky Doctoral Dissertations (3)
- Center for Research on Environmental Disease Faculty Publications (2)
- DNP Projects (2)
- Institute for Biomedical Informatics Faculty Publications (2)
- Molecular and Cellular Biochemistry Faculty Publications (2)
- Pathology and Laboratory Medicine Faculty Publications (2)
- Pharmaceutical Sciences Faculty Publications (2)
- Pharmacy Practice and Science Faculty Publications (2)
- Radiology Faculty Publications (2)
- Spinal Cord and Brain Injury Research Center Faculty Publications (2)
- Theses and Dissertations--Music (2)
- Theses and Dissertations--Pharmacology and Nutritional Sciences (2)
- Anesthesiology Faculty Publications (1)
- Center for Microelectrode Technology Faculty Publications (1)
- Chemistry Faculty Publications (1)
- Electrical and Computer Engineering Faculty Publications (1)
- Epidemiology and Environmental Health Faculty Publications (1)
- Publication Type
Articles 151 - 154 of 154
Full-Text Articles in Medicine and Health Sciences
Role Of Reactive Oxygen Species Peroxynitrite In Traumatic Spinal Cord Injury, Yiqin Xiong
Role Of Reactive Oxygen Species Peroxynitrite In Traumatic Spinal Cord Injury, Yiqin Xiong
University of Kentucky Doctoral Dissertations
Peroxynitrite (PN, ONOO-), formed by nitric oxide radical (•NO) and superoxide radical (O2•-), plays an important role in post-traumatic oxidative damage. In the early work, we determined the temporal characteristics of PN-derived oxidative damage in a rat spinal cord injury (SCI) model. Our results showed 3-nitrotyrosine (3-NT), a specific marker for PN, rapidly accumulated at early time points (1 hr, 3 hrs), after when it plateaued and the high level was sustained to 1 week post injury. The co-localization of 3-NT and lipid peroxidation derived-4-HNE observed in immunohistochemistry indicates PN is involved in lipid peroxidative as …
Functional Properties Of L-Glutamate Regulation In Anesthetized And Freely Moving Mice, Kevin N. Hascup
Functional Properties Of L-Glutamate Regulation In Anesthetized And Freely Moving Mice, Kevin N. Hascup
Theses and Dissertations--Neuroscience
L-glutamate (Glu) is the predominant excitatory neurotransmitter in the mammalian central nervous system with involvement encompassing learning and memory, cognition, plasticity, and motor movement. Dysregulation of the glutamatergic system is implicated in several neurological disorders including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis. The mechanisms underlying these neurological disorders are not clear, but evidence suggests that abnormal Glu neurotransmission plays a role. Elevated levels of Glu in the synaptic cleft overstimulate the N-methyl-Daspartate receptor leading to excitotoxicity, which causes neuronal loss in chronic neurological diseases. What is less understood is the source for the elevated Glu levels. …
Prenatal Cocaine Exposure Alters Alpha2 Receptor Expression In Adolescent Rats, Rosemarie M. Booze, David R. Wallace, Janelle M. Silvers, Barbara J. Strupp, Diane M. Snow, Charles F. Mactutus
Prenatal Cocaine Exposure Alters Alpha2 Receptor Expression In Adolescent Rats, Rosemarie M. Booze, David R. Wallace, Janelle M. Silvers, Barbara J. Strupp, Diane M. Snow, Charles F. Mactutus
Neuroscience Faculty Publications
BACKGROUND: Prenatal cocaine exposure produces attentional deficits which to persist through early childhood. Given the role of norepinephrine (NE) in attentional processes, we examined the forebrain NE systems from prenatal cocaine exposed rats. Cocaine was administered during pregnancy via the clinically relevant intravenous route of administration. Specifically, we measured alpha2-adrenergic receptor (alpha2-AR) density in adolescent (35-days-old) rats, using [3H]RX821002 (5 nM).
RESULTS: Sex-specific alterations of alpha2-AR were found in the hippocampus and amygdala of the cocaine-exposed animals, as well as an upregulation of alpha2-AR in parietal cortex.
CONCLUSION: These data suggest that prenatal cocaine exposure results in a persistent alteration …
Cyclooxygenase-2 Mediates Microglial Activation And Secondary Dopaminergic Cell Death In The Mouse Mptp Model Of Parkinson's Disease, Rattanavijit Vijitruth, Mei Liu, Dong-Young Choi, Xuan V. Nguyen, Randy L. Hunter, Guoying Bing
Cyclooxygenase-2 Mediates Microglial Activation And Secondary Dopaminergic Cell Death In The Mouse Mptp Model Of Parkinson's Disease, Rattanavijit Vijitruth, Mei Liu, Dong-Young Choi, Xuan V. Nguyen, Randy L. Hunter, Guoying Bing
Neuroscience Faculty Publications
BACKGROUND: Accumulating evidence suggests that inflammation plays an important role in the progression of Parkinson's disease (PD). Among many inflammatory factors found in the PD brain, cyclooxygenase (COX), specifically the inducible isoform, COX-2, is believed to be a critical enzyme in the inflammatory response. Induction of COX-2 is also found in an experimental model of PD produced by administration of 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
METHOD: COX-2-deficient mice or C57BL/6 mice were treated with MPTP to investigate the effects of COX-2 deficiency or by using various doses of valdecoxib, a specific COX-2 inhibitor, which induces inhibition of COX-2 on dopaminergic neuronal toxicity and …