Medicine and Health Sciences Commons^™

Effect Of Dietary Treatment With Stearidonic Acid And Eicosapentaenoic Acid On Membrane Phospholipid Fatty Acid Composition And Glycogen-Elicited Peritoneal Neutrophil Survival In Absence Or Presence Of Bacterial Endotoxin, Jonathan Earl Phipps

Masters Theses

We previously found that enteral nutrition with diets containing elevated levels of eicosapentaenoic acid (EPA; 20:5 n-3) reduced the number of neutrophils in bronchoalveolar lavage fluid and improved clinical outcome of patients with or at risk for adult respiratory distress syndrome (ARDS). We have also shown that the treatment of the neutrophil-like cell line, HL-60, with EPA can induce apoptosis. It is not known, however, if the addition of EPA to the diet would result in similar occurrences in neutrophils.

It has been suggested that the use of diets enriched with stearidonic acid (SDA; 18:4 n-3) may provide a novel …

Hsv-1 Induced Ocular Angiogenesis: Antiangiogenic Strategies To Prevent Herpetic Stromal Keratitis Pathogenesis, Bum Seok Kim

Doctoral Dissertations

Herpetic stromal keratitis (SK) is an immunopathological and tissue destructive corneal lesion caused by herpes simplex virus (HSV) infection, which induces an intense autoimmune inflammatory response and finally leads blindness. Accumulating evidence using the murine model has shown that Th-1 phenotype CD4⁺ T cells orchestrating the inflammation mainly contribute the immunopathological reaction in HSV-1 infected cornea. However, prior to CD4⁺ T cell infiltration into corneal lesions, various innate immune cells recruit and produce numerous inflammatory molecules into the corneal stroma. Interestingly, one prominent event early in the pathogenesis of SK is neovascularization of the usually avascular cornea. It …

Polycyclic Aromatic Hydrocarbons From The Chattanooga Creek Flood Plain And Their Effects On Endothelial Cells Via Group Ivc Phospholipase A2, Meghan Scott Mcneilly

Masters Theses

Exposure to environmental pollution can be a contributing factor to the development of cardiovascular disease (CVD). Due to contamination produced by long-term discharge of coal tar wastes into the creek, a 2.5-mile section of the Chattanooga Creek in south Chattanooga was designated as a Superfund site by the USEPA in 1994. In order to further investigate the potential health risks posed by creek contamination, 12 PAHs found in high levels in the sediment of the creek as compared to an uncontaminated control site were evaluated for their effects on the human coronary artery endothelial cell (HCAEC) phospholipase A_{2 (PLA2)/arachidonic …}