Medicine and Health Sciences Commons^™

Implementation Of A Home-Based Walking Program To Address Cancer-Related Fatigue, Mary Catherine Hyatt, Karen Lasater, Michelle Payne

Graduate Publications and Other Selected Works - Doctor of Nursing Practice (DNP)

Abstract

Background: The non-treatment of cancer-related fatigue (CRF) in adult oncology patients on treatment is a clinical practice issue identified globally and at the local Hematology and Oncology Clinic. Despite the growing evidence supporting physical activity to address CRF, this problem remains prominent. Objective: An 8-week home-based walking program was implemented at the local clinic to address this problem. This project aimed to increase the prevalence of managing CRF and reduce the severity of CRF. Methods: With the provider's recommendation, adult oncology patients on active treatment at the Hematology and Oncology Clinic registered for the program in …

Non-Opioid Pain Relief: Use Of Vitamin D In Central Appalachia, Christina Brown, Karen Lasater, Teresa Tyson

Graduate Publications and Other Selected Works - Doctor of Nursing Practice (DNP)

Background: Overdose deaths have exceeded US war fatalities since WWII. Central Appalachia faces high substance use rates and poor health determinants. The opioid epidemic costs $740 billion annually. Providing 100 million chronic pain sufferers alternative pain control is efficacious, equitable, and reduces opioids. The author collaborated with a nurse-led mobile clinic in Central Appalachia to identify evidence-based non-opioid pain relief options for practice translation. In patients with hypovitaminosis D, the body will increase parathyroid hormone production to absorb calcium resulting in skeletal or muscular pain. Vitamin D’s steroid properties reduce inflammation by dampening proinflammatory cytokines. Framework: The Johns Hopkins Nursing …

Anti-Inflammatory And Chemopreventive Activity Of Lunasin From Tofu Whey For The Management Of Gastrointestinal Diseases, Cindy Andrea Nieto Veloza

Doctoral Dissertations

Gastrointestinal diseases such as inflammatory bowel diseases (IBD) and colorectal cancer (CRC) are pathological conditions associated with chronic inflammation, characterized by intestinal damage, debilitating symptoms, and detrimental health consequences. The increased risk of CRC in IBD patients, and the adverse effects associated with current therapeutic strategies, point out the need for safer alternatives to reduce chronic inflammation in the bowel. Lunasin is a bioactive peptide naturally occurring in soybeans, with chemopreventive and anti-inflammatory properties demonstrated in several extra-intestinal diseases. However, to date, there is no evidence of the biological activity of lunasin on the gastrointestinal tract as a target site. …

Psychedelics Can Save: The Scientific And Social Case For Rescheduling Psychedelic Compounds, Galen M. Fader

Chancellor’s Honors Program Projects

No abstract provided.

A Review Of Horticultural Therapy And Horticultural Therapy Education In The United States: Addressing Challenges And Opportunities, Derrick R. Stowell

Doctoral Dissertations

The Horticultural Therapy (HT) profession has been formally organized in the United States since 1973. Despite the long history of horticulture being used as therapy, the profession of HT in the United States has not advanced as quickly as other allied healthcare professions. This study will review the current challenges and opportunities for HT and HT education in the United States.

A qualitative study of the status of the profession was conducted to determine what challenges and opportunities the profession of HT currently has and how the profession can meet those challenges and opportunities. The study sample was recruited from …

Investigation Of Zyflamend On Ampk Signaling And Potential Interactions Of Its Components, Yi Zhao

Doctoral Dissertations

The reductionist approach contributes greatly to our understanding of anticancer properties of phytonutrients, but in vitro studies demand concentrations that are 100-1000 times higher than achievable in humans, producing results with little physiologic relevance, resulting in disappointing outcomes in clinical trials. However, maintaining these bioactives in the presence of other compounds originally derived from the food/extract of origin may synergistically lower the bioactive dose so translatability becomes feasible. The first objective of this study was to determine if bioefficacy of phytonutrients can be enhanced when used in combination at doses that are ineffective when used in isolation. In this project, …

Anesthesia Of The Geriatric Equine, Reza Seddighi Dvm, Ms, Phd, Dip Acva, Cvma

Faculty Publications and Other Works -- Large Animal Clinical Sciences

Advancements in veterinary medicine have resulted in an increased number of geriatric horses being presented for medical or surgical procedures that require general anesthesia. Due to the physiological changes associated with aging and the likelihood of concurrent disease conditions, the geriatric equine is at an increased risk during anesthesia. The main physiological changes associated with aging, and their impact on anesthesia, are discussed in this review.

Identification Of Novel Molecular Targets Of Resveratrol In Colorectal Carcinogenesis, Nichelle Chantil Whitlock

Doctoral Dissertations

Current research suggests resveratrol, a phytoalexin found predominately in grapes, may function as a chemopreventive and/or chemotherapeutic agent for various cancers, including colorectal cancer. However, the underlying mechanism(s) involved in these activities remain elusive. Thus, the objective of the studies discussed here sought to investigate the effect of resveratrol treatment on gene modulation in human colorectal cancer cells in order to identify and characterize novel molecular targets that contribute to the observed anticancer activities of resveratrol. Here, we identify activating transcription factor 3 (ATF3) and early growth response-1 (Egr-1) as novel targets of resveratrol and provide data to elucidate the …

Gene Alterations By Peroxisome Proliferator-Activated Receptor Gamma Agonists In Human Colorectal Cancer Cells, Maria Cekanova, X Li, J Yuan, K B. Kim, Seung J. Baek

Faculty Publications and Other Works -- Biochemistry, Cellular and Molecular Biology

The peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear transcription factor that controls the genes involved in metabolism and carcinogenesis. In the present study, we examined the alteration of gene expression in HCT-116 human colorectal cancer cells by PPARgamma agonists: MCC-555 (5 microM), rosiglitazone (5 microM), and 15-deoxy-Delta12,14-prostaglandin J2 (1 microM). The long-oligo microarray data revealed a list of target genes commonly induced (307 genes) and repressed (32 genes) by tested PPARgamma agonists. These genes were analyzed by Onto-Express software and KEGG pathway analysis and revealed that PPARgamma agonists are involved in cell proliferation, focal adhesion, and several signaling pathways. …

Effect Of Dietary Treatment With Stearidonic Acid And Eicosapentaenoic Acid On Membrane Phospholipid Fatty Acid Composition And Glycogen-Elicited Peritoneal Neutrophil Survival In Absence Or Presence Of Bacterial Endotoxin, Jonathan Earl Phipps

Masters Theses

We previously found that enteral nutrition with diets containing elevated levels of eicosapentaenoic acid (EPA; 20:5 n-3) reduced the number of neutrophils in bronchoalveolar lavage fluid and improved clinical outcome of patients with or at risk for adult respiratory distress syndrome (ARDS). We have also shown that the treatment of the neutrophil-like cell line, HL-60, with EPA can induce apoptosis. It is not known, however, if the addition of EPA to the diet would result in similar occurrences in neutrophils.

It has been suggested that the use of diets enriched with stearidonic acid (SDA; 18:4 n-3) may provide a novel …

Hsv-1 Induced Ocular Angiogenesis: Antiangiogenic Strategies To Prevent Herpetic Stromal Keratitis Pathogenesis, Bum Seok Kim

Doctoral Dissertations

Herpetic stromal keratitis (SK) is an immunopathological and tissue destructive corneal lesion caused by herpes simplex virus (HSV) infection, which induces an intense autoimmune inflammatory response and finally leads blindness. Accumulating evidence using the murine model has shown that Th-1 phenotype CD4⁺ T cells orchestrating the inflammation mainly contribute the immunopathological reaction in HSV-1 infected cornea. However, prior to CD4⁺ T cell infiltration into corneal lesions, various innate immune cells recruit and produce numerous inflammatory molecules into the corneal stroma. Interestingly, one prominent event early in the pathogenesis of SK is neovascularization of the usually avascular cornea. It …

Polycyclic Aromatic Hydrocarbons From The Chattanooga Creek Flood Plain And Their Effects On Endothelial Cells Via Group Ivc Phospholipase A2, Meghan Scott Mcneilly

Masters Theses

Exposure to environmental pollution can be a contributing factor to the development of cardiovascular disease (CVD). Due to contamination produced by long-term discharge of coal tar wastes into the creek, a 2.5-mile section of the Chattanooga Creek in south Chattanooga was designated as a Superfund site by the USEPA in 1994. In order to further investigate the potential health risks posed by creek contamination, 12 PAHs found in high levels in the sediment of the creek as compared to an uncontaminated control site were evaluated for their effects on the human coronary artery endothelial cell (HCAEC) phospholipase A_{2 (PLA2)/arachidonic …}

Inhibition Of Angiogenesis Using Rnai Technology, Yunsang Lee

Doctoral Dissertations

Ocular infection of Herpes Simplex Virus-1 (HSV-1) causes Herpetic Stromal Keratitis (HSK), which is a leading cause of infectious blindness. Although complex interactions of molecular and cellular events involve in the department of HSK, it has been known that angiogenesis is a key step for the HSK pathogenesis. Treatment of neutralizing antibody against vascular endothelial growth factor (VEGF) to inhibit VEGF activity reduced angiogenesis and HSK severity caused by infection of HSV-1 in mouse eyes. In addition, inactivation of cytokine which induces VEGF production and angiogenesis also reduced angiogenesis and HSK severity. Therefore, it has been proposed that VEGF or …