Research Methods in Life Sciences Commons^™

State-Dependent Learning As A Function Of The Temporal Relationship Between Noncontingent Footshock And Electroconvulsive Shock, T. Scott Shutt

All Master's Theses

Rats were given a noncontingent footshock followed at various intervals by electroconvulsive shock. Twentyfour hours later they were trained on a non-shock passive avoidance task and tested for retention 72 hours later. When the interval between NCFS and ECS was short the animals showed an amnesia which reduced as the interval was lengthened. An interval of .5 seconds produced the most pronounced amnesia and intervals greater than 10 seconds produced virtually no amnesia. The results were consistent with a state dependent retrieval failure hypothesis.

Root Exposure And Its Effect On The Fluid Movement Within The Tooth, William J. Busch

Loma Linda University Electronic Theses, Dissertations & Projects

This study examined the fluid movement in dentin associated with the exposure of the root surface for varying periods of time ranging from 75 minutes to 30 days. Eight kittens received experimental defects on the roots of the canines. Just prior to sacrifice a fluorescing dye was injected intraperitoneally to make the fluid within the dentin visible under ultraviolet light. Frozen ground sections were prepared and examined. The results showed that the exposed side of the root had a reduced amount of fluid fluorescence when compared to the opposite side of the tooth which had an intact root surface. The …

The Cathartic Effects Of Aggressive Responses Directed Toward An Inanimate Object, Timothy William Creston

All Master's Theses

This study was intended to test the catharsis of aggression hypothesis which in part holds that aggressive responses directed towards an inanimate object will have a tension reducing effect and result in a lowering of residual hostility.

Cardioregulatory Role Of The Abdominal Ganglion Of Aplysia Californica, George Maeda

Loma Linda University Electronic Theses, Dissertations & Projects

An isolated heart-abdominal ganglion preparation of this mollusc was developed and used to study the cardioregulatory function of the ganglion and nerves. The heart was perfused with artificial sea water through an atrial cannula and the gastro-esophageal artery was catheterized for blood pressure monitoring. The presence and cardioregulatory effects of axons in the nerves was investigated by electrical stimulation. Fine-tipped glass microelectrodes inserted into ganglionic neurons were used to determine the relationship between the neuronal and cardiac activities.

The principal results are listed below.

1. Primarily inhibitory responses are obtained from both right and left connective stimulation, with some evidence for …

Sub-Aversive Response Contingent Foot Shock As A Positive Reinforcer, Robert Lea Fulwiler

All Master's Theses

Forty-eight rats were divided into 8 groups; four were maintained under normal conditions and the other four under sensory deprivation and tested at o, 3, 6, and 9 days after condition institution. The response was placing the head through a hole in the operant chamber and the stimulus (0, 1.2, 4, or 12 Vac) was contingent upon the response. Analysis ot variance disclosed significant differences (p<.01) between the deprived and the non-deprived groups at days 6 and 9; and a significant interaction between deprivation condition and time of test. No differences were shown between the stimulus intensities indicating that the stimulus did not have a reinforcing effect.

The Effect Of Elevated Glucose On Neutrophilic Phagocytosis In Genetically Diabetic Mice, Larry B. Thompson

Loma Linda University Electronic Theses, Dissertations & Projects

Infiltration to an injury site or area of bacterial contamination by polymorphonuclear leucocytes (or neutrophils) is an early and essential phase of the early inflammatory reaction. Their action on foreign matter is the most critical step taken by body defense mechanisms in the first 24 hours. Anything which interferes with that action, phagocytosis, greatly hampers early inflammation. This study was designed to see the effect of elevated glucose levels on neutrophil phagocytosis in a unique strain of genetically diabetic mice.

Twenty-two diabetic and twenty-four control female mice were used. Blood glucose determinations and total white counts were made on each …

The Response Of Gingival Tissues To Alterations In Ph, Robert C. Jann

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to evaluate the histopathological and clinical changes that occurred when a continuous supply of exogenous acid or base, at varying pH, was delivered adjacent to the gingival crest of the monkey. A related goal was to develop a monkey model system which would deliver test solutions continuously and atraumatically, to the experimental gingival sites.

Two young adult female monkeys had a perfusion apparatus attached to certain maxillary teeth so that test solutions were deposited atraumatically to the marginal gingival tissues. During the experimental periods the animals were kept in primate restraining chairs and fed …

The Effects Of Cs Habituation And Duration Of The Directional Modification Of The Cardiac Response In The Guinea Pig (Cavia Procellus), Ray Charles Larson

All Master's Theses

The present experiment examined the effects of CS habituation and two different levels of CS duration (60 versus 6 sec) on the directional modification of the conditioned cardiac response in the guinea pig. The results indicated that the only reaction to the CS, regardless of prior habituation or CS duration, was a decelerative conditioned HR response. However, habituation to a CS prior to classical aversive conditioning was found to attenuate the magnitude of the bradycardia CR that developed. The bradycardia CR was discussed in terms of being a cardiac component of the orienting response.