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Articles 1 - 2 of 2
Full-Text Articles in Research Methods in Life Sciences
Amelioration Of Prenatal Alcohol Effects By Environmental Enrichment In A Mouse Model Of Fasd, Aniruddho Chokroborty-Hoque
Amelioration Of Prenatal Alcohol Effects By Environmental Enrichment In A Mouse Model Of Fasd, Aniruddho Chokroborty-Hoque
Electronic Thesis and Dissertation Repository
Maternal alcohol consumption during pregnancy results in a spectrum of behavioural and cognitive deficits collectively known as Fetal Alcohol Spectrum Disorders (FASD). Currently, little is know about if and how the external environment may modulate these deficits. I have used C57BL/6 mice to study this interaction between prenatal alcohol exposure and the postnatal environment. Alcohol exposure during synaptogenesis produces high levels of anxiety-like traits and decreased memory performance. Alcohol-exposed mice (and matched unexposed controls) were put in 'environmentally-enriched' conditions of voluntary exercise, physical activities and cognitive stimulation to ascertain the effects of a positive postnatal environment. The results show that …
Characterization Of An 18f-Growth Hormone Secretagogue Probe For Positron Emission Tomography Imaging Of The Growth Hormone Secretagogue Receptor, Ahmed Abbas
Electronic Thesis and Dissertation Repository
Cardiovascular disease affects 1.6 million Canadians, of whom one-third have heart failure (HF). HF is diagnosed by imaging investigations and detection of circulating biomarkers. Most of the current imaging strategies study morphologic and gross functional changes, but fall short of imaging molecular abnormalities associated with HF. Biomarkers offer molecular targets; however, clinical biomarkers circulate systemically and are not cardiac-specific. Thus, there is critical need for a biomarker that is endogenous to myocardial tissues. The growth hormone secretagogue receptor 1a (GHSR1a), which binds the hormone ghrelin, is expressed by cardiomyocytes and is elevated in HF patients. This study characterized the specificity …