Open Access. Powered by Scholars. Published by Universities.®
Research Methods in Life Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Animal Experimentation and Research (4)
- Biology (3)
- Genetics and Genomics (3)
- Neuroscience and Neurobiology (3)
- Cell and Developmental Biology (2)
-
- Laboratory and Basic Science Research (2)
- Molecular Genetics (2)
- Molecular and Cellular Neuroscience (2)
- Pharmacology, Toxicology and Environmental Health (2)
- Physiology (2)
- Behavioral Neurobiology (1)
- Botany (1)
- Cellular and Molecular Physiology (1)
- Developmental Biology (1)
- Developmental Neuroscience (1)
- Ecology and Evolutionary Biology (1)
- Evolution (1)
- Genetics (1)
- Other Genetics and Genomics (1)
- Pharmacology (1)
- Plant Biology (1)
- Plant Sciences (1)
- Keyword
-
- Acridocarpus (1)
- Alcohol (1)
- Biogeographic disjunction (1)
- Brachylophon (1)
- CYCLOIDEA2 (CYC2) (1)
-
- Craniofacial (1)
- Crosstalk (1)
- Development (1)
- Developmental Cortical Malformation (1)
- Drosophila melanogaster (1)
- Drug-resistant Epilepsy (1)
- Erbb3b (1)
- Ethanol (1)
- Expression regulation (1)
- Face (1)
- Floral ontogeny (1)
- Floral symmetry evolution (1)
- Gene knockout mice (1)
- Genetics (1)
- Head twitch response (1)
- Inflammation (1)
- Krameria lanceolata Torrey (1)
- Krameriaceae (1)
- Malpighiaceae (1)
- Mouth (1)
- Neural crest migration (1)
- Neuroblastoma (1)
- Neurocristopathies (1)
- ODE model (1)
- Oil-bee pollination syndrome (1)
Articles 1 - 7 of 7
Full-Text Articles in Research Methods in Life Sciences
Dynamic Mathematical Approaches To Understanding Pain In Sickle Cell Disease, Quindel Jones
Dynamic Mathematical Approaches To Understanding Pain In Sickle Cell Disease, Quindel Jones
Theses and Dissertations
In the last 50 years, pain in Sickle Cell Disease (SCD) has become more widely studied thanks to advancements in technology and awareness. Clinical studies, population surveys, pharmaceutical trials, and computational models have been created and conducted to elucidate the mechanisms, treatments, and prediction of Sickle Cell disease pain episodes. Computational models have become quite useful in unraveling disease pathology with the rise in data collection accessibility and advanced computational power. In particular, dynamic mathematical models have been used to investigate Sickle Cell disease pathology and treatment. In this work we conduct a literature review of mathematical models used in …
Epithelial Membrane Protein 3 (Emp3b) Is A Novel Regulator Of Sympathetic Nervous System Development In Zebrafish., Jessica M. White
Epithelial Membrane Protein 3 (Emp3b) Is A Novel Regulator Of Sympathetic Nervous System Development In Zebrafish., Jessica M. White
Theses and Dissertations
Notable progress has been made in understanding the development of the neural crest (NC). Neural crest cells (NCCs) can be divided into 4-5 subpopulations. A major lineage among trunk NC derivatives are sympathoadrenal (SA) cells, which give rise to the sympathetic nervous system (SNS). Trunk NCCs follow a ventromedial migration pathway where signals derived from the dorsal aorta instruct migrating NCCs to a SA cell fate. Defects in NC development can result in syndromes known as neurocristopathies. Neuroblastoma is one of the most common forms of pediatric cancer affecting nearly 800 infants each year in the United States (Takita et …
Identifying Genes Downstream Of Mef2 That Influence Ethanol Sedation In Drosophila Melanogaster, Ananya Talikoti
Identifying Genes Downstream Of Mef2 That Influence Ethanol Sedation In Drosophila Melanogaster, Ananya Talikoti
Theses and Dissertations
Alcohol use disorder is a global public health issue that affects millions across the world. It can result in negative physical and mental health outcomes, and currently treatment options are limited and rates of relapse are high. Identifying genes that affect aspects of ethanol behaviors in model organisms, such as Drosophila melanogaster, can serve to eventually develop more robust therapeutic interventions for those experiencing alcohol dependence. Previous studies have identified a relationship between a person's initial sensitivity to alcohol and their abuse potential for the drug in later life. Therefore, we can study sedation behaviors in Drosophila melanogaster to …
Focal Augmentation Of Somatostatin Interneuron Function And Subsequent Circuit Effects In Developmentally Malformed, Epileptogenic Cortex, Nicole Ekanem
Theses and Dissertations
Drug-resistant epilepsy (DRE) is a common clinical sequela of developmental cortical malformations such as polymicrogyria. Unfortunately, much remains unknown about the aberrant GABA-mediated circuit alterations that underlie DRE's onset and persistence in this context. To address this knowledge gap, we utilized the transcranial freeze lesion model in optogenetic mice lines (Somatostatin (SST)-Cre or Parvalbumin (PV)-Cre x floxed channelrhodopsin-2) to dissect features of the SST, PV, and pyramidal neuron microcircuit that are potentially associated with DRE. Investigations took place within developmental microgyria’s known pathological substrate, the adjoined and epileptogenic paramicrogyral region (PMR). As well, microcircuit relationships within the previously unexplored range …
Molecular Targets Of Psychedelics And Their Role In Behavioral Models Of Hallucinogenic Action, Hiba Z. Vohra
Molecular Targets Of Psychedelics And Their Role In Behavioral Models Of Hallucinogenic Action, Hiba Z. Vohra
Theses and Dissertations
Psychedelics are a subset of hallucinogenic drugs that exert their characteristic effects through agonist activity at the serotonin receptor 2A (5-HT2A). In this study, I aimed to characterize the modulatory role of the metabotropic glutamate subtype 2 receptor (mGluR2) in the 5-HT2A-specific rodent model of hallucinogenic action, head-twitch response (HTR). Secondly, I aimed to explore if 5-HT2A agonist-induced deficits in prepulse inhibition (PPI) of the startle response, an additional model of hallucinogenic action, could be produced in mice. Though 5-HT2A agonist-induced PPI deficits, which represent interruptions in normal sensorimotor gating, have been described in …
Floral Symmetry Genes Elucidate The Development And Evolution Of Oil-Bee Pollinated Flowers Of Malpighiaceae And Krameriaceae, Farahnoz N. Khojayori
Floral Symmetry Genes Elucidate The Development And Evolution Of Oil-Bee Pollinated Flowers Of Malpighiaceae And Krameriaceae, Farahnoz N. Khojayori
Theses and Dissertations
Specialization on insect and animal pollinators is thought to be the driving force for the evolution of floral traits. Specifically in the New World (NW), the oil-bee pollination syndrome has led to the convergence of floral characters in two distantly related families of core eudicots, Malpighiaceae and Krameriaceae. Both families display a flag-like structure that establishes a zygomorphic flower and floral oil rewards in epithelial elaiophores. These traits work concomitantly to attract and reward female oil-bees that help fertilize these flowers and in return receive oils. The underlying genetics of floral zygomorphy were studied in several clades of core eudicots, …
Zebrafish (Danio Rerio) As A Model For Orofacial Research, Kevin A. Ghaffari
Zebrafish (Danio Rerio) As A Model For Orofacial Research, Kevin A. Ghaffari
Theses and Dissertations
Across species, the face and more specifically the mouth, serves as an essential facet of everyday life. Amongst humans the mouth serves as a tool for the ingestion of food, a marker for facial recognition and a medium for communication. In order for the mouth to properly form, a series of precise growth and fusion events are needed. In order to insure that these events are orchestrated properly is a wide array of signals, transcription factors and epigenetic regulators. Due to the needed precision of these events, congenital birth defects of the face such as cleft lip and cleft palate …