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The Relationship Of Alcohol Consumption In Rats To Morphine And Codeine Intake And The Metabolism Of Dopamine, Hsiu Fen Liu
The Relationship Of Alcohol Consumption In Rats To Morphine And Codeine Intake And The Metabolism Of Dopamine, Hsiu Fen Liu
Loma Linda University Electronic Theses, Dissertations & Projects
The effects of morphine and codeine free-choice alcohol consumption in male Sprague-Dawley rats were studied. Intakes of a 10% alcohol solution in milliliters per 100 gm. of body weight were on recorded weekly. No difference was found in the alcohol intake of rats given either a morphine-supplemented diet (0.01% of the diet) or daily injection of morphine sulfate (2 mg./kg.); however, there was a significant lower intake of water (p < .05) in those rats fed the diet with morphine. Total fluid consumption of both groups given the morphine-supplemented diet and daily injection of morphine sulfate was decreased (p < .05). It was found that morphine did not affect the percentage of total fluid consumed as alcohol or the weight gain.
Two levels of codeine phosphate (10 mg./kg. and 20 mg./kg.) were injected subcutaneously into rats twice a day. It was observed that the codeine significantly decreased alcohol intake in rats …
Effects Of Cocaine, Nicotine And Diet On Voluntary Alcohol Consumption In Rats, Zaida Raquel Cordero Loayza
Effects Of Cocaine, Nicotine And Diet On Voluntary Alcohol Consumption In Rats, Zaida Raquel Cordero Loayza
Loma Linda University Electronic Theses, Dissertations & Projects
The consumption of alcohol is a problem not only in this country (U.S.), but also in many other places in the world. Thus we find the Indians in Peru, Bolivia and other neighboring countries (Ecuador and northern part of Argentina) consuming alcohol to the point that they become alcoholics, in addition to this they also chew coca leaves, plant from which cocaine is extracted.
In an effort to establish the cause for this behavior, we put Sprague-Dawley albino rats on either a poor or good basal diet. Once every other day the rats were injected with a solution of cocaine. …