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Possible Breakdown Of Dopamine Receptor Synergism In A Mouse Model Of Huntington's Disease, Samantha F. Kennedy
Possible Breakdown Of Dopamine Receptor Synergism In A Mouse Model Of Huntington's Disease, Samantha F. Kennedy
University of New Orleans Theses and Dissertations
The model of basal ganglia function proposed by Albin, Young and Penney (1989) describes two anatomically independent motor pathways, the direct and indirect. However, under normal conditions striatal dopamine (DA) is required for the expression of motor behavior, and DAergic control of the two pathways (via D1 and D2 receptors, respectively) is dependent on co-activation. We tested for a possible breakdown of D1/D2 synergism using transgenic R6/1 mice bearing the human huntingtin allele (Htt). Motor stereotypy, observed prior to the onset of HD-related symptoms, was rated on a 5-point scale following activation of: A) D1 receptors alone, B) D2 receptors …
Functional Analysis And Treatment Of Self-Injurious Feather Plucking In A Black Vulture (Coragyps Atratus), Kristen L. Morris
Functional Analysis And Treatment Of Self-Injurious Feather Plucking In A Black Vulture (Coragyps Atratus), Kristen L. Morris
Thesis Projects
Feather plucking (FP) is a maladaptive behavior observed in captive avian species. This self-injurious behavior results in damage to and removal of feathers and skin tissue, resulting in animal welfare and financial consequences. The etiology and maintenance of FP have been hypothesized through medical and environmental processes, yet a definitive solution has not been found. The current study investigated the environmental variables maintaining the FP of a Black Vulture (Coragyps atratus), as well as evaluated a function-based treatment for this behavior. The behavior was found to be maintained by positive reinforcement in the form of contingent attention. Treatment …