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Full-Text Articles in Physiology
Mechanisms That Limit Oxidative Phosphorylation During High-Intensity Muscle Contractions In Vivo, Miles F. Bartlett
Mechanisms That Limit Oxidative Phosphorylation During High-Intensity Muscle Contractions In Vivo, Miles F. Bartlett
Doctoral Dissertations
Skeletal muscle oxidative capacity plays a critical role in human health and disease. Although current models of oxidative phosphorylation sufficiently describe skeletal muscle energetics during moderate-intensity contractions, much is still unknown about the mechanisms that control and limit oxidative phosphorylation during high-intensity contractions. In particular, the oxygen cost of force generation is augmented during exercise at workloads above the lactate threshold. Presently, it is unclear whether this augmentation in muscle oxygen consumption is driven by increased rates of oxidative ATP synthesis (ATPOX) or by decreases in the efficiency of ATPOX due to mitochondrial uncoupling. To address this …
Effects Of Electrical Pulse Stimulation On In Vitro Measurement Of Mitochondrial Content And Lipid In Human Myotubes, Daniel Alberto Conde
Effects Of Electrical Pulse Stimulation On In Vitro Measurement Of Mitochondrial Content And Lipid In Human Myotubes, Daniel Alberto Conde
Open Access Theses & Dissertations
It has been previously shown that human myotubes retain certain in vivo characteristics of the donors. Furthermore, we have shown that Electrical pulse stimulation (EPS), an in vitro exercise mimetic, increases mitochondrial and lipid content in cultured human myotubes after 24 hr. of stimulation. Purpose: We aimed to examine the EPS induced adaptations to lipid, mitochondrial, and Glucose transporter 4 (GLUT4) content using human myotubes. Methods: EPS was applied to myotubes for 60 min (bipolar pulses of 100 Hz, 30V, every 5 seconds), 24 hr. or 48 hr. (single bipolar pulses of 1 Hz for 2 ms; 30V) and were …
Effect Of An Endurance Training-Overtraining Protocol On Rat Muscular Oxidative Capacity, Rodrigo Luiz Perroni Ferraresso, Denise Vaz De Macedo, Rodrigo Hohl
Effect Of An Endurance Training-Overtraining Protocol On Rat Muscular Oxidative Capacity, Rodrigo Luiz Perroni Ferraresso, Denise Vaz De Macedo, Rodrigo Hohl
International Journal of Exercise Science: Conference Proceedings
Overtraining may outcomes for functional overreaching (FOR), a short term decline in performance that leads eventually to an improvement in performance after recovery, or nonfunctional overreaching (NFOR) when performance decline may be reversed only by a longer regenerative period. Recently we developed a training-overtraining protocol for rats with increased workload: eight weeks of daily exercise sessions, followed by three weeks of increasing daily training frequency (2, 3 and 4 times) with decreasing recovery time between sessions (4, 3 and 2h), characterized by analyses of performance before training (T1) and after the 4th(T2), 8th(T3), 9th(T4), 10th(T5) and 11th(T6) training weeks. All …