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2023

Stress

Articles 1 - 5 of 5

Full-Text Articles in Physiology

Microglial Response To Glucocorticoids During Chronic Sleep Fragmentation, Christian Chelson Aug 2023

Microglial Response To Glucocorticoids During Chronic Sleep Fragmentation, Christian Chelson

Masters Theses & Specialist Projects

Sleep is one of the body’s greatest and most basic needs. Chronic sleep loss (<6 hours a day) is linked to many cardiovascular issues, diabetes, and inflammatory conditions and has been shown to lower life expectancy. Obstructive sleep apnea (OSA) is a complication that causes sleep fragmentation in >8% of adults from developed countries, and many with OSA may be unaware of their condition. Having long-term OSA is linked to neuroinflammation caused by activated microglia in the brain, but the mechanics of this inflammation are not well understood. It is known that glucocorticoids, steroid hormones produced and released from the adrenal glands, have a suppressive effect on microglia. The purpose of this study is to explore the role that glucocorticoids have upon microglia activation induced by chronic sleep fragmentation (SF). C57BL/6J mice were …

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Role Of Chronic Stress-Induced Neuroinflammation In Rodent Locus Coeruleus Physiology And Anxiety-Like Behaviors, Arthur Anthony Alfonso Reyes Jun 2023

Role Of Chronic Stress-Induced Neuroinflammation In Rodent Locus Coeruleus Physiology And Anxiety-Like Behaviors, Arthur Anthony Alfonso Reyes

Graduate School of Biomedical Sciences Theses and Dissertations

The locus coeruleus (LC), the primary site of brain norepinephrine (NE), is a key anatomical brain region implicated in the stress response. Stress is a neuroendocrine physiologic response to a stressor that promotes organism survival through adaptive change and restoration of homeostasis. The central stress response, which drives behavioral and physiological change, is primarily mediated by activating the hypothalamic-pituitary-adrenal (HPA) axis. While advantageous in the short term, chronic stress exposure can lead to HPA axis and LC dysregulation, which are thought to contribute to the etiology of anxiety disorders. Previous studies demonstrate the effects of acute stress in increasing LC …

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A Comparison Of Continuous And Interval Exercise On Cognition In Young Adults, Emily C. Tagesen, Lawrence W. Judge, David M. Bellar Mar 2023

A Comparison Of Continuous And Interval Exercise On Cognition In Young Adults, Emily C. Tagesen, Lawrence W. Judge, David M. Bellar

International Journal of Exercise Science

International Journal of Exercise Science 16(5): 458-468, 2023. Exercise stimulates the production and secretion of testosterone, cortisol, and brain-derived neurotrophic factor (BDNF) and affects cognitive performance. However, the interaction of these variables is unknown. To investigate these interactions, 21 college-aged men completed two work-matched exercise protocols: continuous (CONT) exercise and an interval protocol (INT). Blood and saliva samples were collected before and after exercise to quantify BDNF, cortisol, and testosterone. Participants completed a battery of cognitive assessments after exercise. A MANOVA analysis of condition demonstrated that no domains were significantly different after CONT and INT (p > 0.05). A repeated …

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Salivary Cortisol Analysis In Collegiate Female Lacrosse Athletes, Jenna L. Carter, Stephanie L. Mathews, Yvette L. Figueroa, Jennifer A. Bunn Feb 2023

Salivary Cortisol Analysis In Collegiate Female Lacrosse Athletes, Jenna L. Carter, Stephanie L. Mathews, Yvette L. Figueroa, Jennifer A. Bunn

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 242-251, 2023. Cortisol is a hormone that corresponds to physiological and emotional stress. The purpose of this study was to 1) evaluate the changes in cortisol in female Division I collegiate lacrosse players (n = 15) throughout the competitive season, and 2) evaluate the correlation between cortisol and athlete wellness and workload. Salivary cortisol samples were collected weekly in the morning throughout the entirety of the 2021 competitive season (12 weeks). Subjective athlete total wellness scores and sub-scores (muscle soreness, sleep quality, fatigue, and stress) were taken on the same days. Objective total …

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The Metabolic And Physiological Demands Of A Simulated Fire Ground Test Versus A Live-Fire Training Evolution In Professional Firefighters, Drew Edward Gonzalez, Hunter Waldman, Matthew J. Mcallister Feb 2023

The Metabolic And Physiological Demands Of A Simulated Fire Ground Test Versus A Live-Fire Training Evolution In Professional Firefighters, Drew Edward Gonzalez, Hunter Waldman, Matthew J. Mcallister

International Journal of Exercise Science

International Journal of Exercise Science 16(7): 230-241, 2023. Objective: This study examined the similarities in metabolic and physiological demands of a fire ground test (FGT) and a live fire training evolution. Methods: Twenty-seven firefighters completed either a FGT (n = 13) or a live fire training evolution (n = 14). Salivary samples were collected pre, immediately post, and 30-minutes post FGT and live fire training evolution, and analyzed for cortisol, uric acid, and interleukin-1β (IL-1β). Heart rate (HR) was measured pre- and post-task. Results: Both tasks resulted in significant elevations in cortisol, IL-1β, and HR. Conclusions: Both the …

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