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Articles 1 - 4 of 4
Full-Text Articles in Physiology
Comparison Of Theophylline And 8-Cyclopentyltheophylline On The Heart Rates Of Neonatal Rats, Stephanie Arnold
Comparison Of Theophylline And 8-Cyclopentyltheophylline On The Heart Rates Of Neonatal Rats, Stephanie Arnold
Undergraduate Honors Theses
Neonatal apnea is a serious condition that affects the health of infants, especially those born prematurely. To stimulate breathing, methylxanthine drugs, such as theophylline and caffeine, are administered to reverse this condition in humans and avoid the use of breathing-assistance equipment. These drugs cause stimulation of the central nervous system and the heart, however, both detrimental side effects in preterm infants. Antagonism of adenosine receptors is the proposed mechanism of methylxanthine action. Synthetic chemists have produced xanthine analogs with increased affinity for adenosine receptors that could lead to respiratory stimulation while reducing cardiostimulant effects. For this study, theophylline and 8-cyclopentyltheophylline …
Improved Tolerance To Salt And Water Stress In Drosophila Melanogaster Cells Conferred By Late Embryogenesis Abundant Protein, Matthew R. Marunde, Dilini A. Samarajeewa, John Anderson, Shumin Li, Steven C. Hand, Michael A. Menze
Improved Tolerance To Salt And Water Stress In Drosophila Melanogaster Cells Conferred By Late Embryogenesis Abundant Protein, Matthew R. Marunde, Dilini A. Samarajeewa, John Anderson, Shumin Li, Steven C. Hand, Michael A. Menze
Faculty Research & Creative Activity
Mechanisms that govern anhydrobiosis involve the accumulation of highly hydrophilic macromolecules, such as late embryogenesis abundant (LEA) proteins. Group 1 LEA proteins comprised of 181 (AfLEA1.1) and 197 (AfLEA1.3) amino acids were cloned from embryos of Artemia franciscana and expressed in Drosophila melanogaster cells (Kc167). Confocal microscopy revealed a construct composed of green fluorescence protein (GFP) and AfLEA1.3 accumulates in the mitochondria (AfLEA1.3-GFP), while AfLEA1.1-GFP was found in the cytoplasm. In the presence of mixed substrates, oxygen consumption was statistically identical for permeabilized Kc167 control and Kc167-AfLEA1.3 cells. Acute titrations of permeabilized cells with NaCl up to 500 mM led …
Diapause And Anhydrobiosis In Embryos Of Artemia Franciscana: Metabolic Depression, Lea Proteins And Water Stress, Steven C. Handel, Yuvraj Patil, Shumin Li, Nilay Chakraborty, Apurva Borcar, Michael A. Menze, Leaf C. Boswell, Daniel Moore, Mehmet Toner
Diapause And Anhydrobiosis In Embryos Of Artemia Franciscana: Metabolic Depression, Lea Proteins And Water Stress, Steven C. Handel, Yuvraj Patil, Shumin Li, Nilay Chakraborty, Apurva Borcar, Michael A. Menze, Leaf C. Boswell, Daniel Moore, Mehmet Toner
Faculty Research & Creative Activity
Metabolic depression is typically correlated with extended survival of environmental challenge and energy-limitation in early life stages of various invertebrates and vertebrates. Diapause is an ontogenetically-programmed reduction of development and often metabolism seen in many invertebrates. When embryos of Artemia franciscana enter the state of diapause, the overall metabolic depression is estimated to be greater than 99%. These embryos also contain trehalose and express multiple isoforms of Late Embryogenesis Abundant (LEA) proteins, constituents often present in a number of such anhydrobiotic animals. The mRNA levels for LEA proteins are highest in diapause and post-diapause embryos that possess desiccation tolerance, but …
Eccentric Resistance Training And Blood Flow Restriction, Zachary Pope
Eccentric Resistance Training And Blood Flow Restriction, Zachary Pope
Masters Theses
The purpose of this study was to compare the muscular strength and hypertrophic response following a four week training intervention involving resistance exercise utilizing only eccentric muscle contractions with, or without blood flow restriction (BFR), as well as a control group maintaining their current training regimen. Sixteen young male volunteers were recruited to participate in this study. Prior to the training intervention, subjects attended three sessions in order to obtain demographic information (age, height, body mass) and familiarize each of the participants with the testing and training equipment. After the familiarization session, muscular strength was assessed via elbow flexion one …