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Testing The Effect Of Antioxidants On The Pathogenesis Of Alzheimer’S Disease Through The Rage/Nf-Kb Inflammatory Pathway, Harrison Snyder, Jonathan Wisco
Testing The Effect Of Antioxidants On The Pathogenesis Of Alzheimer’S Disease Through The Rage/Nf-Kb Inflammatory Pathway, Harrison Snyder, Jonathan Wisco
Journal of Undergraduate Research
The Receptor for Advanced Glycation Endproducts (RAGE) is known to have a role in inflammatory processes. When produced in excess it induces oxidative stress by activating a number of ligand enzymes, resulting in the generation of excessive cytosolic reactive oxidant species. This oxidative stress then stimulates Nuclear Factor Kappa-B (NF-kB), which regulates immune response and inflammation. When RAGE is incorrectly regulated, inflammation occurs in otherwise healthy tissue, a process implicated in neurodegenerative disorders like Alzheimer’s disease. RAGE is found throughout the body and is seen in greater concentration in inflamed tissues; it has also been found in the brain tissue …