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Oxidative Stress Analysis Of Placental Tissue In The Rupp Pregnant Rat, Natalie Ganios
Oxidative Stress Analysis Of Placental Tissue In The Rupp Pregnant Rat, Natalie Ganios
Williams Honors College, Honors Research Projects
Preeclampsia is a disease associated with a vasoconstrictive phenotype due to disrupted signaling in the vascular endothelial growth factor (VEGF) relaxation pathway. The purpose of these studies is to determine the level of oxidative damage that is occurring in the placenta of the reduced uterine perfusion pressure (RUPP) rat, which serves as a common model for preeclampsia. RUPP and SHAM placenta tissue will be examined for oxidative stress as an indicator of tissue damage associated with the pathologically induced ischemia. Oxidative stress in the placental tissue will be measured by performing the following oxidative stress assays: 8-isoprostane test, TBARS assay, …