Physiology Commons^™

The Effect Of Feeding, Bilateral Parotidectomy, And Pilocarpine Treatment On Parotid Hormone Secretion In The Pig, Jocelyn Celestin

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of feeding, bilateral parotidectomy, pilocarpine treatment, visual and olfactory, and masticatory stimuli on parotid hormone (PH) secretion is reported. Feeding a regular chow was shown to be a potent stimulus for PH secretion. The parotid endocrine system is highly sensitive to the eating stimulus, since a period of feeding lasting 30 sec is enough to cause a significant increase in PH secretion. The parotid glands are the principal source of PH as shown by the marked decrease in basal PH titer, and a virtual absence of response of PH to feeding in parotidectomized pigs. Pilocarpine administration provoked profuse …

Vascular Effects Of Physalia Physalis Venom, Jose S. Loredo

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to identify the effects of Physalia physalis (Portuguese Man-of-War) venom on vascular smooth muscle and elucidate its mode of action. We utilized the in vivo approach by functionally isolating the skeletal muscle vasculature of the dog's hind leg, and the in vitro approach by studying rabbit arterial ring segments.

Twelve male mongrel dogs were anesthetized with 35 mg/kg sodium pentobarbital. Arterial pressure was measured from the aortic arch and the cranial femoral artery, a cephalad branch of the femoral artery. The skeletal muscle venous blood flow of the hind leg was functionally isolated. Femoral …

Effects Of The Removal Of Adherent And Phagocytic Cells On The Spleen Cell Lymphoproliferative Response Of Tumor Bearing Mice, Aileen M. Hyde

Loma Linda University Electronic Theses, Dissertations & Projects

Cell-mediated immunity was investigated in two BALB/c mouse tumor systems using the lymphocyte transformation test with phytohemagglutinin as the mitogen. This lymphoproliferative response was quantitated using the Stimulation Index (SI). Spleen cells from mice injected with #51 cells, a chemically-transformed colon cell line, produced a SI value equal to that of normal mice. There was no evidence for suppressor cell activity in cell mixing experiments in which spleen cells from #51 cell-injected mice were mixed with spleen cells from normal mice. Following macrophage removal by Sephadex G-10 columns an d carbonyl iron ingestion, there were no significant changes in the …