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Full-Text Articles in Physiology
Forward Genetic Screen To Identify Novel Genes Involved In Nhej Dna Repair, Taylor Brown, Dr. Jonathan Alder
Forward Genetic Screen To Identify Novel Genes Involved In Nhej Dna Repair, Taylor Brown, Dr. Jonathan Alder
Journal of Undergraduate Research
DNA contains all the information a cell needs to grow, divide, differentiate, and survive. It also dictates how and when a cell should die. DNA damage (particularly double strand breaks i.e. DSBs) may lead to cell death and/or disease. To circumvent DNA breaks, cells use various DNA repair mechanisms including non-homologous end joining (NHEJ). My ORCA research project focused on identifying novel genes involved in NHEJ. I did this by performing a forward genetic screen (FGS) that tested every known gene in the genome for involvement in NHEJ.