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Examining The Potential Role Of Gpr18 And Gpr119 In Learning And Memory, Brandon Anderson, James Kranewitter-Call, Dr. Jeffrey Edwards
Examining The Potential Role Of Gpr18 And Gpr119 In Learning And Memory, Brandon Anderson, James Kranewitter-Call, Dr. Jeffrey Edwards
Journal of Undergraduate Research
Many mental disorders plague our society. Dementia and Alzheimer’s disease have greatly impacted many victims and their families. Despite the seriousness and pervasiveness of Alzheimer’s, there is still no effective treatment for it nor the accompanying dementia. GPR18 and GPR119 are G-protein coupled receptors (GPRs) and have been identified in the central nervous system, but their functional role is unknown. Many successful drugs target GPR proteins, so examining these GPRs’ function in the brain could lead to potential targets leading to innovative medical advances.
Memory is dependent on a molecular process called synaptic plasticity. In synaptic plasticity, the strength of …