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Measuring The Effects Of High-Fat Diet On Breathing And Oxygen-Sensitivity Of The Carotid Body Type I Cell, Ryan J. Rakoczy
Measuring The Effects Of High-Fat Diet On Breathing And Oxygen-Sensitivity Of The Carotid Body Type I Cell, Ryan J. Rakoczy
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The carotid bodies (CB), the primary peripheral chemoreceptors, respond to changes in blood gases with neurotransmitter release, thereby increasing carotid sinus nerve firing frequency and ultimately correcting the pattern of breathing. It has previously been demonstrated that acute application of the adipokine leptin caused perturbations of intracellular calcium and membrane ion movement in isolated CB Type I cells (Pye et al, 2015) and augmented the response of the intact CB to hypoxia (Pye et al, 2016). This study's aim was to examine, in-vivo, if elevated leptin modulated CB function and breathing. Rats were fed high-fat chow or control chow for …
The Use Of Doublecortin To Quantify The Effects Of Pharmacological Treatment On Neurogenesis And Functional Recovery After Stroke, Amber Lee Hensley
The Use Of Doublecortin To Quantify The Effects Of Pharmacological Treatment On Neurogenesis And Functional Recovery After Stroke, Amber Lee Hensley
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Ischemic strokes account for 87% of all strokes and can have debilitating effects on language, sensory, and motor skills. Currently, tPA is the only medication approved by the FDA for the treatment of ischemic stroke, but the window of time to administer the drug is very small. In this thesis, we investigate the use of a simvastatin and fluoxetine drug combination (FS) as a possible treatment for ischemic stroke victims. To analyze the effects of FS on neurogenesis and functional recovery, we utilize the Montoya Staircase and quantify the amount of neurogenesis using doublecortin. Although the results of this study …
Correlations Between Sensory Encoding And Central Morphology Of Muscle Proprioceptors In The Rat, Hanna Marie Gabriel
Correlations Between Sensory Encoding And Central Morphology Of Muscle Proprioceptors In The Rat, Hanna Marie Gabriel
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Until now, observations regarding the central morphology and organization of Ia, group II and Ib Golgi tendon organ afferents have been confined to the cat model. As the use of rodents in the study of the development and organization of segmental spinal cord circuitry increases, a complete account of the peripheral encoding and central connectivity of rodent muscle proprioceptors is necessary. The data presented in this study establish the central morphology and spatial distribution of 12 (4 of each class) functionally phenotyped muscle proprioceptor afferents in the rat by intracellular labeling with Neurobiotin. Each afferent type showed a characteristic central …