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Evaluation Of A Monosynaptic Spinal Circuit In Multiple Mouse Models Of Amyotrophic Lateral Sclerosis, Maura A. Curran
Evaluation Of A Monosynaptic Spinal Circuit In Multiple Mouse Models Of Amyotrophic Lateral Sclerosis, Maura A. Curran
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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. To date, there are no significant disease-modifying treatments, and one limiting factor in treatment is the amount of time it takes for a patient to receive a diagnosis of ALS. This study examined multiple mouse models before symptom onset to help identify early changes in a reflex circuit of ALS mice. Dorsal root stimulation of the sacral spinal cord in multiple models ALS mouse models showed changes in the resulting ventral root compound action potential amplitude, latency, and ability to maintain synaptic depression. These data also suggest that a mouse model …
Protocol Development And Optimization For Rnls Mouse Characteristic Assessment, Hasan Farid
Protocol Development And Optimization For Rnls Mouse Characteristic Assessment, Hasan Farid
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Protocol development and optimization are vital in the scientific method process. By having accurate protocols, one can properly assess the characteristics of their animal model for any given experiment. One animal newly adopted in our lab was the novel regulatable nuclear localization sequence (rNLS) mouse model. This novel mouse model displays symptoms of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FTD), after the accumulation of the hTDP-43 (TAR DNA-binding protein 43) aggregate in the central nervous system. The expression of this protein occurs after the removal of deoxycycline from the mouse’s food source. Once the removal of the drug, this …