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Estimating The Variables Of The Nonlinear Dynamical Theory Of Acute Cell Injury, Fika Tri Anggraini
Estimating The Variables Of The Nonlinear Dynamical Theory Of Acute Cell Injury, Fika Tri Anggraini
Wayne State University Dissertations
This Dissertation is the first to estimate the variables D and S of the nonlinear theory of acute cell injury in hippocampal regions CA1 and CA3 using a rat model of global brain ischemia and reperfusion (I/R). D was estimated by quantifying protein aggregates using ubiquitin Western blotting. S was estimated by quantifying changes in polysomal mRNAs as measured by microarray chips. D and S time courses were sampled at 0.5, 8, 16, 24, 48, and 72 hrs of reperfusion after 10 min brain ischemia. CA1 dies and CA3 survives. The theory predicts D will be larger in CA1 and …
Ribonomic Control During Global Brain Ischemia And Reperfusion, Haihui Wang
Ribonomic Control During Global Brain Ischemia And Reperfusion, Haihui Wang
Wayne State University Dissertations
Abstract
RIBONOMIC CONTROL DURING GLOBAL BRAIN ISCHEMIA AND REPERFUSION
by HAIHUI WANG
August 2014
Advisor: Donald J. DeGracia, Ph.D.
Major: Physiology
Degree: Doctor of Philosophy
The study presented here used "omic" technology to look at the mechanism behind the selective delayed death of hippocampus CA1 neurons after transient global brain ischemia. The main findings are summarized:
1. The main form of ELAV protein family member detected in CA1/CA3 in Hu protein immunoprecipitation and polysomes was HuB (Rel-N1). HuB is present in control CA3, 8 hr reperfused CA3, and 8 hr reperfused CA1, but absent from control CA1. AUF-1, hnRNP K, …