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- Adaptive fetal programming (1)
- Animal wellbeing (1)
- Boar (1)
- Developmental biology (1)
- Developmental origins of health and disease (1)
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- DoHAD (1)
- FGR (1)
- Fetal growth restriction (1)
- Fetal programming (1)
- GNRH2 (1)
- GNRHR2 (1)
- Growth hormone (1)
- IUGR (1)
- Luteinizing hormone (1)
- Muscle hypertrophy (1)
- Neuroendocrinology (1)
- Porcine testis (1)
- RFamide-related peptide 3 (1)
- Stress in exotic species (1)
- Stress-responsive biomarkers (1)
- Testosterone (1)
Articles 1 - 5 of 5
Full-Text Articles in Physiology
Mid-Gestation Maternofetal Inflammation Impacts Growth, Skeletal Muscle Glucose Metabolism, And Inflammatory Tone In The Ovine Fetus During Late Gestation, Zena Hicks
Department of Animal Science: Dissertations, Theses, and Student Research
Our 1st and 2nd studies assessed the impact of mid-gestation maternofetal inflammation on growth, skeletal muscle glucose metabolism, and inflammatory tone in the late gestation ovine fetus. The objective was to determine if inducing maternofetal inflammation during peak placental growth would lead to more profound IUGR characteristics in the fetus. MI-IUGR fetuses exhibited reduced body and skeletal muscle weights and hallmark asymmetric growth at late gestations. Fetuses had higher baseline glucose:insulin ratios and reduced glucose-stimulated insulin secretion. Moreover, hindlimb glucose oxidation was impaired independent of glucose uptake. Skeletal muscle specific glucose uptake and oxidation was reduced in MI-IUGR …
The Role Of Inflammatory Pathways In Development, Growth, And Metabolism Of Skeletal Muscle In Iugr Offspring; Blood Gene Expression Of Inflammatory Factors As Novel Biomarkers For Assessing Stress And Wellbeing In Exotic Species., Robert J. Posont
Department of Animal Science: Dissertations, Theses, and Student Research
Our first study identified the effects of maternal inflammation-induced intrauterine growth restriction (MI-IUGR) on growth and muscle glucose metabolism in offspring supplemented with curcumin. MI-IUGR lambs exhibited asymmetric growth restriction at birth and 30d of age, but normal glucose-stimulated insulin secretion. Hindlimb glucose oxidation was reduced by MI-IUGR and not improved by curcumin supplementation. Ex vivo muscle glucose oxidation was reduced by MI-IUGR but improved somewhat by curcumin. These finding indicate that fetal programming responses to MI contribute to neonatal growth and metabolic deficits. Neonatal curcumin supplementation had minimal effect on growth deficits but may improve glucose metabolism. …
Lh-Independent Testosterone Secretion Is Mediated By The Interaction Between Gnrh2 And Its Receptor Within Porcine Testes, Amy T. Desaulniers, Rebecca A. Cederberg, Ginger A. Mills, J. Joe Ford, Clay A. Lents, Brett R. White
Lh-Independent Testosterone Secretion Is Mediated By The Interaction Between Gnrh2 And Its Receptor Within Porcine Testes, Amy T. Desaulniers, Rebecca A. Cederberg, Ginger A. Mills, J. Joe Ford, Clay A. Lents, Brett R. White
Department of Animal Science: Faculty Publications
Unlike classic gonadotropin-releasing hormone 1 (GNRH1), the second mammalian isoform (GNRH2) is an ineffective stimulant of gonadotropin release. Species that produce GNRH2 may not maintain a functional GNRH2 receptor (GNRHR2) due to coding errors. A full-length GNRHR2 gene has been identified in swine, but its role in reproduction requires further elucidation. Our objective was to examine the role of GNRH2 and GNRHR2 in testicular function of boars. We discovered that GNRH2 levels were higher in the testis than in the anterior pituitary gland or hypothalamus, corresponding to greater GNRHR2 abundance in the testis versus the anterior pituitary gland. Moreover, GNRH2 …
The Role Of Rfamide-Related Peptide 3 (Rfrp3) In Regulation Of The Neuroendocrine Reproductive And Growth Axes Of The Boar, Jennifer F. Thorson, Amy T. Desaulniers, Chanho Lee, Brett R. White, J. Joe Ford, Clay A. Lents
The Role Of Rfamide-Related Peptide 3 (Rfrp3) In Regulation Of The Neuroendocrine Reproductive And Growth Axes Of The Boar, Jennifer F. Thorson, Amy T. Desaulniers, Chanho Lee, Brett R. White, J. Joe Ford, Clay A. Lents
Department of Animal Science: Faculty Publications
RFamide-related peptide 3 (RFRP3) has been implicated in regulating reproduction and growth. This regulation appears to be dependent upon sex, species, physiological status, and developmental stage. The objective of the present study was to evaluate the effects of RFRP3 on circulating concentrations of luteinizing hormone (LH) and growth hormone (GH) in mature boars. The hypothesis was RFRP3 would reduce circulating concentrations of LH and increase concentrations of GH. Meishan boars (716.6±2.8 days of age; 125.0±12.4kg BW) were randomly assigned to treatment: saline (n=4) or RFRP3 (8.5mg; n=5). Plasma was collected at 15-min intervals during 3 periods: pre-treatment, treatment, and post-treatment. …
Systems Biology In Animal Breeding: Identifying Relationships Among Markers, Genes, And Phenotypes [Breeding And Genetics Symposium], John B. Cole, Ronald M. Lewis, C. Maltecca, S. Newman, K. M. Olson, R. G. Tait
Systems Biology In Animal Breeding: Identifying Relationships Among Markers, Genes, And Phenotypes [Breeding And Genetics Symposium], John B. Cole, Ronald M. Lewis, C. Maltecca, S. Newman, K. M. Olson, R. G. Tait
Department of Animal Science: Faculty Publications
The Breeding and Genetics Symposium titled “Systems Biology in Animal Breeding: Identifying relationships among markers, genes, and phenotypes” was held at the Joint Annual Meeting of the American Society of Animal Science and the American Dairy Science Association in Phoenix, Arizona, July 15-19, 2012. The primary goal of the symposium was to demonstrate the use of high-density SNP genotypes to determine the complex regulatory relationships among genotypes and phenotypes but also to present methods for studying complex relationships among phenotypes. Case studies from mammalian and avian species were included to emphasize the broad applicability of these methods.