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Full-Text Articles in Physiology
Functional Compartmentalization Of Mlck In Fetal Arteries, Dane William Sorensen
Functional Compartmentalization Of Mlck In Fetal Arteries, Dane William Sorensen
Loma Linda University Electronic Theses, Dissertations & Projects
Changes in vascular structure and reactivity are amongst the most important that occur during the transition from fetal to newborn life, and are guided by the principle of ensuring adequate coupling of blood flow to metabolism. A clinical consequence of maladaptive fetal vascular adaptation to hypoxia is an increased probability for loss of cerebral autoregulation, increased risk for neonatal encephalopathy, and hypoxicischemic cerebral injury. MLCK is a very specific calcium-calmodulin dependent enzyme, with its only known substrate being MLC20, and is essential for the ability of VSMCs within resistance arteries to appropriately contract or relax in response to changes in …
Cosyntropin As A Therapeutic Intervention Following Traumatic Brain Injury, Lorraine C. Siebold
Cosyntropin As A Therapeutic Intervention Following Traumatic Brain Injury, Lorraine C. Siebold
Loma Linda University Electronic Theses, Dissertations & Projects
Traumatic brain injury (TBI) is a major health concern in the United States. With over two million occurrences and approximately 50,000 deaths annually, TBI is a leading cause of death in young adults and is associated with cognitive deficits influenced by acute and persistent neuroinflammation. Melanocortins, such as adrenocorticotropic hormone (ACTH), are agonists for melanocortin receptors located in the adrenal glands and peripheral immune cells as well as throughout the central nervous system. Melanocortins ameliorate inflammation and provide a novel therapeutic approach for TBI. The focus of this dissertation was to describe and quantify effects of cosyntropin, a synthetic ACTH …