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Maternal-Fetal Interactions And The Induction Of Preeclampsia By Growth Arrest-Specific 6 (Gas6)/Axl Signaling, Todd Dunaway, Paul Reynolds
Maternal-Fetal Interactions And The Induction Of Preeclampsia By Growth Arrest-Specific 6 (Gas6)/Axl Signaling, Todd Dunaway, Paul Reynolds
Journal of Undergraduate Research
Preeclampsia (PE) is a complicated obstetric complication characterized by increased blood pressure and decreased trophoblast invasion. PE is one of the leading causes of maternal and fetal morbidity and mortality in developed countries. The growth arrest-specific 6 (Gas6) protein is known to induce different responses in cells including prevention of apoptosis and enhanced cell migration and invasion. This protein is secreted in response to growth arrest and it is increased in the serum of PE patients. This discovery suggests a mechanistic role for the Gas6 signaling pathway during PE progression. Gas6 binds to the AXL tyrosine kinase receptor and AXL-mediated …