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Full-Text Articles in Physiology
Effects Of Blocking Tlr 4 And Rage On The Progression Of Oa In The Tmj, David Mecham, David Kooyman
Effects Of Blocking Tlr 4 And Rage On The Progression Of Oa In The Tmj, David Mecham, David Kooyman
Journal of Undergraduate Research
Osteoarthritis is a degenerative disease of the cartilage that affects more than 80% of Americans above the age of 65 (1). Many adults also suffer from Temporomandibular joint dysfunction (TMD), and 80% of such individuals eventually develop Temporomandibular joint associated Osteoarthritis (TMJ OA) (2). Current pharmaceutical options target symptoms of OA, but there are no known treatments available. Research is being undertaken to elucidate the root causes of the disease at a cellular level. Our lab has previously shown that mice lacking the Receptor for Advanced Glycation End Products are protected from OA (3). Other researchers have shown that blocking …