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Full-Text Articles in Physiology
Strategies For Protection Of The Blood Brain Barrier In Rodent Models Of Intracerebral Hemorrhage, Derek Sunil Nowrangi
Strategies For Protection Of The Blood Brain Barrier In Rodent Models Of Intracerebral Hemorrhage, Derek Sunil Nowrangi
Loma Linda University Electronic Theses, Dissertations & Projects
Intracerebral Hemorrhage (ICH) is a devastating disease that causes a cascade of both mechanical and molecular injury to the central nervous system. It is a debilitating disease that has no well-established treatments, thus leaving an important area to study the pathophysiology of the disease so that new clinically translatable treatments can be found. In the development of translational treatments in experimental ICH, several challenges exist including the designing of studies, method to deliver drugs, proper dosages, and development of models. In our exploration to establish new therapies for ICH, we studied several methods and models that may help to develop …
Harnessing Blood Clot Removal Mechanisms After Germinal Matrix Hemorrhage, Jerry J. Flores
Harnessing Blood Clot Removal Mechanisms After Germinal Matrix Hemorrhage, Jerry J. Flores
Loma Linda University Electronic Theses, Dissertations & Projects
Germinal matrix hemorrhage (GMH) is one of the leading causes of morbidity, mortality, and acquired infantile hydrocephalus in preterm infants in the United States, with little progress made in its clinical management. Blood clots have been shown to elicit secondary brain injury after GMH, by disrupting normal cerebrospinal fluid circulation and absorption after germinal matrix hemorrhage causing post-hemorrhagic hydrocephalus development. Current evidence suggests that rapid hematoma resolution is necessary to quickly improve neurological outcomes after hemorrhagic stroke. N-formyl peptide receptor 2 (FPR2), a G-protein-coupled receptor, has been shown to be neuroprotective after stroke. FPR2 activation has been associated with the …