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Role Of Eps15 Homology Domain-Containing Protein 4 (Ehd4) In The Kidney, Shamma Rahman
Role Of Eps15 Homology Domain-Containing Protein 4 (Ehd4) In The Kidney, Shamma Rahman
Theses & Dissertations
In the kidney, endocytic recycling regulates the abundance of channels and transporters in the membrane of the tubular epithelium, and thereby controls the kidney’s ability to regulate water homeostasis. In recent years, a family of proteins called Eps15 homology domain-containing (EHD) proteins has emerged as important regulators of the endocytic recycling pathway. Mammals express four paralogs of EHD proteins, EHD1-4, that are expressed in different tissues. Although EHD4 is expressed in the kidney, the specific physiological role of EHD4 in the kidney remains unknown. Therefore, this dissertation was focused to elucidate the physiological role of EHD4 in the kidney. In …