Physiology Commons^™

Resistant Hypertension: Risk Factors, Subclinical Atherosclerosis, And Comorbidities Among Adults—The Brazilian Longitudinal Study Of Adult Health (Elsa-Brasil), Paulo A. Lotufo

Paulo A Lotufo

The frequency of resistant hypertension—defined as blood

pressure (BP) ≥140/90 mm Hg with proven use of three

antihypertensive medications, or as the use of four antihypertensive drug classes regardless of BP—is unknown in low-middle–income countries. Using data from the Brazilian Longitudinal Study of Adult Health, a cohort of 15,105 civil servants aged 35 to 74 years, the authors identified 4116 patients taking treatment for hypertension, 11% of who had resistant hypertension. These participants were more likely to be older, black, less educated, poorer, and obese. The adjusted prevalence ratios (95% confidence intervals) were diabetes, 1.44 (1.20–1.72); glomerular filtration rate ( …

Pathscan Enabler At Md Anderson Cancer Center, George Mcnamara

George McNamara

McNamara 20140703 - Additional Pathscan and Tiki_Goddess related resources

http://works.bepress.com/gmcnamara/52

http://home.earthlink.net/~tiki_goddess/

http://works.bepress.com/gmcnamara/1/

http://works.bepress.com/gmcnamara/11/

https://www.linkedin.com/in/georgemcnamara

Our Pathscan Enabler IV, delivered July 2014, uses the QuickScan software to scan a histology slide in "two clicks" (after loading the

slide):

1. Push the QuickScan button on the front of the Pathscan Enabler.

2. Click the Scan button in the QuickScan pop-up application (optional: change scan area in the Prescan image window).

The image gets saved as a TIFF file to the Windows 7 (64-bit) desktop.

I have been using Pathscan Enabler's since version I in 2000. See Chantrain et al 2003:

Chantrain CF, …

Propiconazole Is A Specific And Accessible Brassinosteroid (Br) Biosynthesis Inhibitor For Arabidopsis And Maize., Burkhard Schulz, Thomas Hartwig, Claudia Corvalan, Norman Best, Joshua Budka, Sunghwa Choe

Burkhard Schulz

Brassinosteroids (BRs) are steroidal hormones that play pivotal roles during plant development. In addition to the characterization of BR deficient mutants, specific BR biosynthesis inhibitors played an essential role in the elucidation of BR function in plants. However, high costs and limited availability of common BR biosynthetic inhibitors constrain their key advantage as a species-independent tool to investigate BR function. We studied propiconazole (Pcz) as an alternative to the BR inhibitor brassinazole (Brz). Arabidopsis seedlings treated with Pcz phenocopied BR biosynthetic mutants. The steady state mRNA levels of BR, but not gibberellic acid (GA), regulated genes increased proportional to the …

Mutations In Pmr5 Result In Powdery Mildew Resistance And Altered Cell Wall Composition, John P. Vogel, Ted K. Raab, Chris R. Somerville, Shauna C. Somerville

Ted K. Raab

Powdery mildews and other obligate biotrophic pathogens are highly adapted to their hosts and often show limited host ranges. One facet of such host specialization is likely to be penetration of the host cell wall, a major barrier to infection. A mutation in the pmr5 gene rendered Arabidopsis resistant to the powdery mildew species Erysiphe cichoracearum and Erysiphe orontii, but not to the unrelated pathogens Pseudomonas syringae or Peronospora parasitica. PMR5 belongs to a large family of plant-specific genes of unknown function. pmr5-mediated resistance did not require signaling through either the salicylic acid or jasmonic acid/ ethylene defense pathways, suggesting …

Chemical Bird Repellents: Possible Use In Cyanide Ponds, Larry Clark, Pankaj Shah

Larry Clark

No abstract provided.

Avoidance Of Bird Repellents By Mice, Dale Nolte, J. Russell Mason, Larry Clark

Larry Clark

It is believed that mammalian chemosensory initants are not aver­ sive to birds and vice versa. Nevertheless, few avian repellents have been tested against mammals. For that reason, we evaluated the efficacy of 1.0% w/v methyl anthranilate, orthoaminoacetophenone, 2-amino-4' ,5 '-methoxy­ acetophenone, 2-methoxyacetophenone, and veratryl amine as mouse repel­ lents in 3-hr no-choice drinking tests. Relative to ingestion of plain water, all test substances significantly reduced (P < 0.05) intake. Orthoaminoaceto­phenone was the most effective repellent, with intake reduced to levels sta­tistically indistinguishable from zero.

Evaluation Of A Pelleted Bait Containing Methyl Anthranilate As A Bird Repellent, J. Russell Mason, Larry Clark, Timothy Miller

Larry Clark

No-till agriculture involves the use of granular pesticide formulations, chemically treated seeds, and pelleted baits. Some of these may accidentally kill birds. We have tested whether methyl anthranilate (MA), a known bird repellent, would eliminate consumption of a pelleted bait. In two laboratory experiments and an outdoor aviary trial, cowbirds (Molothrus ater Bodd.) were presented with pellets containing pesticide and MA, pellets containing pesticide but no MA, and carrier pellets without pesticide or MA. Consumption of any formulation was low, but the addition of MA significantly decreased bait loss in the laboratory, and prevented the disappearance of bait in the …

Development Of Chemosensory Attractants For White-Tailed Deer (Odocoileus Virginianus), J. Russell Mason, N. Jay Bean, Larry Clark

Larry Clark

White-tailed deer (Odocoileus spp.) overpopulate many areas of the United States. Browse damage to agricultural crops, forest regeneration and landscaping can be severe. Human and animal health also arc threatened by Lyme disease, which is spread by the deer tick (Ixodes dammini). Although sterilants to reduce and/or slow the growth of deer populations and vaccines against Lyme disease may soon become available, efficient and economical techniques to inoculate large numbers of deer have not been developed. Oral baits represent one promising possibility. In experiment 1, salt blocks and several olfactory lures were evaluated as potential lures for use in deer …

Nonlethal Rodent Repellents: Differences In Chemical Structure And Efficacy From Nonlethal Bird Repellent, Dale Nolte, J. Russell Mason, Larry Clark

Larry Clark

At least some anthranilates (e.g., methyl anthranilate), and ace­ tophenones (e.g., orthoaminoacetophenone) are aversive to mice as well as to birds. Here we systematically examined nine acetophenone isomers (ortho, meta, para) and moieties (amino, hydroxy, methoxy) previously tested as drinking and feeding repellents for European starlings (Sturnus vulgaris). All nine substances reduced intake by mice in single-bottle tests. When molecular characteristics were examined, amino group reactivity and, to a lesser extent, isomeric position (i.e., resonance), were related to the strength of the avoid­ ance response. Unlike effective avian repellents, the presence of intramo lecular hydrogen bonds did not appear to …

Interaction Between Sensory And Postingestional Repellents In Starlings: Methyl Anthranilate And Sucrose, Larry Clark, J. Russell Mason

Larry Clark

Ingestion of concentrated sucrose solutions causes sickness in sucrase-defi­ cie_nt birds. As a result, some suggest that sucrose may represent an environmentally safe avian repellent. In the present experiments, we compared the repellency of sucrose to that of methyl anthranilate (MA), a known avian repellent. We also tested mixtures of sucrose and MA to investigate whether repellency could be enhanced, relative to sucrose or MA presentealo'!e. The results showed that the MA was strongly avoided in both drinking anf edmtnals. Conversely, only high sucrose concentrations were avoided, and only in dnnkmg tnals. No combination of MA and sucrose was as …

Odor Thresholds In Passerines, Larry Clark, K.V. Avilova, N.J. Bean

Larry Clark

Eight species of passerines were evaluated for their ability to form conditioned responses to odor stimuli. Only 5 species met training criteria and were tested for odor detection thresholds.

2. Detection thresholds were comparable to other passerines tested. Detection values were also similar to mammalian macrosmatic species, such as rats and rabbits. Thus, despite the poorly elaborated olfactory anatomy of passerines, these birds possess an adequate sense of smell.

3. Within the Passeriformes there is no correlation between olfactory acuity and relative size of the olfactory bulb. However, there is a correlation between acuity and olfactory bulb size across orders …

Avian Chemical Repellency: A Structure-Activity Approach And Implications, Pankaj Shah, Russell Mason, Larry Clark

Larry Clark

Until recently, the discovery of avian sensory repellents has been empirical (MaRnn, AnAmR 'Inn l;qr\r FlR'l), Hm> !ilv!ilr, recent liltudilillil in our laboratory have shown that many avian repellents have similar perceptual and structural properties (Mason et al. 1989; Mason Clark and Shah 1991; Clark and Shah 1991; Clark, Shah and Mason 1991; Shah, Clark and Mason 1991). For example, methyl anthranilate, which has a grapy odor, is repel­ lent to birds (Kare and Pick, 1960). Ortho-aminoacetophenone has an odor and structure similar to that of methyl anthranilate, differing only in the substitution of a ketone for an ester group …

Taxon-Specific Differences In Responsiveness To Capsaicin And Several Analogues: Correlates Between Chemical Structure And Behavioral Aversiveness, Russell Mason, Jay Bean, Pankaj Shah, Larry Clark

Larry Clark

The present set of experiments was designed to explore avian insensitivity to capsaicin. Based upon a molecular model of avian chemosen­ sory repellency, we hypothesized that structural modifications of the basic capsaicin molecule, which is itself not aversive to birds, might produce aver­ sive analogues. To this end, European starlings (Sturnus vulgaris) and Nor­ way rats (Rattus norvegicus) were given varied concentrations of synthetic capsaicin and four analogues (methyl capsaicin, veratryl amine, veratryl acet­ amide, vanillyl acetamide) in feeding and drinking tests. The results agreed with a model that we are developing to describe the chemical nature of avian repellents. …

The Development Of Effective Endothermy And Homeothermy By Nestling Pition Jays, Larry Clark

Larry Clark

No abstract provided.