Physiology Commons^™

Connectivity Differences Between Gulf War Illness (Gwi) Phenotypes During A Test Of Attention, Tomas Clarke, Jessie Jamieson, Patrick Malone, Rakib U. Rayhan, Stuart Washington, John W. Vanmeter, James N. Baraniuk

Department of Mathematics: Faculty Publications

One quarter of veterans returning from the 1990–1991 Persian Gulf War have developed Gulf War Illness (GWI) with chronic pain, fatigue, cognitive and gastrointestinal dysfunction. Exertion leads to characteristic, delayed onset exacerbations that are not relieved by sleep. We have modeled exertional exhaustion by comparing magnetic resonance images from before and after submaximal exercise. One third of the 27 GWI participants had brain stem atrophy and developed postural tachycardia after exercise (START: Stress Test Activated Reversible Tachycardia). The remainder activated basal ganglia and anterior insulae during a cognitive task (STOPP: Stress Test Originated Phantom Perception). Here, the role of attention …

Alanyl-Trna Synthetase Quality Control Prevents Global Dysregulation Of The Escherichia Coli Proteome, Paul Kelly, Nicholas Backes, Kyle Mohler, Christopher Buser, Arundhati Kavoor, Jesse Rinehart, Gregory Phillips, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Mechanisms have evolved to prevent errors in replication, transcription, and translation of genetic material, with translational errors occurring most frequently. Errors in protein synthesis can occur at two steps, during tRNA aminoacylation and ribosome decoding. Recent advances in protein mass spectrometry have indicated that previous reports of translational errors have potentially underestimated the frequency of these events, but also that the majority of translational errors occur during ribosomal decoding, suggesting that aminoacylation errors are evolutionarily less tolerated. Despite that interpretation, there is evidence that some aminoacylation errors may be regulated, and thus provide a benefit to the cell, while others …

Trade-Offs Between Survival And Reproduction In Starvation-Selected Drosophila Melanogaster, Tammara Beeghly

UNLV Theses, Dissertations, Professional Papers, and Capstones

Evolutionary outcomes are demonstrated by traits that affect an organism’s schedule of reproduction and survival. These life history traits are reflected in an organism’s physiology, development and behavior. Environmental changes, such as availability of nutritional resources, can profoundly affect evolutionary outcomes of individuals and populations. When shortages arise, there will be trade-offs in the allocation of resources, where one trait prevails at the expense of another.

In the laboratory, we can mimic conditions in nature and study the specific effects of the conditions that we re-create. In our case, over 100 generations of Drosophila melanogaster have been selected for starvation …

Bone-Loading Physical Activity And Alcohol Intake But Not Bmi Affect Areal Bone Mineral Density In Young College-Aged Korean Women: A Cross-Sectional Study., Dong Jun Sung, Harshvardhan Singh, Seung-Bum Oh, Sojung Kim

Faculty Scholarship for the College of Science & Mathematics

The purpose of this cross-sectional study was to determine the differences in areal bone mineral density (aBMD) based on alcohol consumption behaviors, bone-loading history as assessed by a bone-specific physical activity questionnaire (BPAQ), and the body mass index (BMI). College-aged female students (N = 112) were recruited from the universities in Seoul and Gyeonggi province, South Korea. The aBMD of the lumbar spine and non-dominant side of the proximal femur (total hip, TH; femoral neck, FN; femoral trochanter, FT) were measured using dual energy X-ray absorptiometry (DXA). Alcohol consumption was determined by the frequency and amount of alcohol intake during …

Examining The Relationship Of Exercise And Sleep In Students Across Multiple Academic Disciplines, Taylor Zewe

Honors Projects

Students in college learn the importance of balancing their academic studies with their sleep and exercise habits. The amount of sleep and exercise a student recieves has been examined in previous research studies. In these studies it was found that exercise had a postive affect on the amount of sleep received. However, there is little research on the affect academic discipline has on sleep habits and/or exercise habits of students in college. The purpose of this study is to examine the sleep and exercise habits among students in multiple academic majors at Bowling Green State University.

The Black Identity, Hair Product Use, And Breast Cancer Scale, Dede Teteh, Marissa Ericson, Sabine Monice, Lenna Dawkins-Moultin, Nasim Bahadorani, Phyllis Clark, Eudora Mitchell, Lindsey S. Treviño, Adana Llanos, Rick Kittles, Susanne Montgomery

Health Sciences and Kinesiology Faculty Articles

Introduction
Across the African Diaspora, hair is synonymous with identity. As such, Black women use a variety of hair products, which often contain more endocrine-disrupting chemicals than products used by women of other races. An emerging body of research is linking chemicals in hair products to breast cancer, but there is no validated instrument that measures constructs related to hair, identity, and breast health. The objective of this study was to develop and validate the Black Identity, Hair Product Use, and Breast Cancer Scale (BHBS) in a diverse sample of Black women to measure the social and cultural constructs associated …

Chronic Muscle Weakness And Mitochondrial Dysfunction In The Absence Of Sustained Atrophy In A Preclinical Sepsis Model, Allison M. Owen, Samir P. Patel, Jeffrey D. Smith, Beverly K. Balasuriya, Stephanie F. Mori, Gregory S. Hawk, Arnold J. Stromberg, Naohide Kuriyama, Masao Kaneki, Alexander G. Rabchevsky, Timothy A. Butterfield, Karyn A. Esser, Charlotte A. Peterson, Marlene E. Starr, Hiroshi Saito

Physiology Faculty Publications

Chronic critical illness is a global clinical issue affecting millions of sepsis survivors annually. Survivors report chronic skeletal muscle weakness and development of new functional limitations that persist for years. To delineate mechanisms of sepsis-induced chronic weakness, we first surpassed a critical barrier by establishing a murine model of sepsis with ICU-like interventions that allows for the study of survivors. We show that sepsis survivors have profound weakness for at least 1 month, even after recovery of muscle mass. Abnormal mitochondrial ultrastructure, impaired respiration and electron transport chain activities, and persistent protein oxidative damage were evident in the muscle of …

The Identification Of Long Non-Coding Rna Zfas1 Through An Exploratory Rna-Sequencing Analysis And Its Association With Epithelial-To-Mesenchymal Transition In Colon Cancer Adenocarcinoma., Stephen J. O'Brien

Electronic Theses and Dissertations

Colorectal adenocarcinoma is the fourth most common cancer diagnosed worldwide and is a significant cause of morbidity and mortality. This dissertation performed an exploratory RNA-sequencing analysis comparing gene expression between colon adenocarcinoma tissue and paired normal colon epithelium. After identification of a number of lncRNAs that were increased in expression in colon adenocarcinoma compared to normal colon epithelium, we aimed to validate the expression and investigate their function in vitro. Specifically, we focused on the lncRNA ZFAS1 and its association with epithelial-to-mesenchymal transition. These studies found the following: 1. Seven candidate lncRNAs were identified from the exploratory RNA-sequencing analysis to …

The Effects Of Caffeine Ingestion On The Hemostatic Response To Simulated Firefighting Activities, Sierra Wassell

Showcase of Graduate Student Scholarship and Creative Activities

The leading cause of death among firefighters is sudden cardiac event, and it is acknowledged that most ischemic events are due to an occlusive thrombus formation. In addition, due to the demanding job requirements and shift work, firefighters are commonly known to overuse caffeine as an ergogenic aid. The purposes of this study were to examine the potential effects of caffeine on the hemostatic response to simulated firefighting activity.

The Effect Of Oral Contraceptives On Caffeine Metabolism And Cycling Performance, Annette M. Lemanski

Showcase of Graduate Student Scholarship and Creative Activities

This project objectives were to determine the effects of oral contraceptives and menstrual cycle on the benefits of caffeine supplementation for cycling performance. Seventeen recreationally trained female cyclists completed four trials consisting of 3 kilometer time trials. Subjects ingested either caffeine or a placebo one hour prior to each trial. The magnitude of the ergogenic aid of caffeine was compared between oral contraceptive users and eumenorreheic females. In addition, the effect of caffeine was compared across different phases of the menstrual cycle, specifically the follicular and luteal phases.

The Role Of Adaptive Immunity In Chronic Hypoxia-Induced Pulmonary Hypertension, Levi David Maston

Biomedical Sciences ETDs

Inflammation is a prominent pathologic feature in pulmonary arterial hypertension as demonstrated by pulmonary vascular infiltration of inflammatory cells, including T and B lymphocytes. However, the contribution of the adaptive immune system is not well characterized in pulmonary hypertension (PH) caused by chronic hypoxia (CH). Inflammatory cells, through various mechanisms, have the capability to increase pulmonary vascular resistance in various disease states. CD4⁺T cells have the potential to play a significant role in the disease process initiated by hypoxia. CD4⁺T cells are largely responsible for orchestrating downstream immune processes and are critical in focusing and amplifying …

Digestive System, Janna Jann '20, Andrew Du '20, Ishan Nikam '20, Nikhilesh Gupta '20

Human Diseases Graphic Novels

No abstract provided.

Addisons Disease, Kailey A. Light '21, Tori Shepherd '21, Jemea Hilmara '20

Human Diseases Graphic Novels

No abstract provided.

Chlamydia, Lauren Pickett '20, Namit Padgaonkar '20, Vidhi Singh '20, Olivia Orobor '20, Samuel Rabideau '20

Human Diseases Graphic Novels

No abstract provided.

Alzheimer's, Sophia Pribus '20, Shivang Bhaskar '20, Pratibha Bhalla '20, Zahra Vasi '20

Human Diseases Graphic Novels

No abstract provided.

Scabies, Srilalana Appasani '21, Prarthana Prashanth '21, Krishna Thakkar '20, Esha Dani '20

Human Diseases Graphic Novels

No abstract provided.

Bell's Palsy Disease, Frances Balto, Grace Federici, Bala Ramaraju, Saisu Talasu

Human Diseases Graphic Novels

No abstract provided.

Tuberculosis, Jodie Meng '20, Shouri Bochetty '21, Elizabeth Murphy '20, Rachel Mason '20

Human Diseases Graphic Novels

No abstract provided.

Melanoma, Esha Dani '20, Krishna Thakkar '20, Prarthana Prashanth '21, Srilalana Appasani '21

Human Diseases Graphic Novels

No abstract provided.

Huntington's Disease, Frances Balto, Grace Federici, Bala Ramaraju, Saisu Talasu

Human Diseases Graphic Novels

No abstract provided.

Pneumonia, Brennan Shapiro '20

Human Diseases Graphic Novels

No abstract provided.

Shingles, Pratibha Bhalla '20, Zahra Vasi '20, Shivang Bhaskar '20, Sophia Pribus '20

Human Diseases Graphic Novels

No abstract provided.

Diabetes, Kailey A. Light '21, Tori Shepherd '21, Jemea Hilmara '20

Human Diseases Graphic Novels

No abstract provided.

Invasion Of The Pollen, Elizabeth Murphy '20, Rachel Mason '20, Jodie Meng '20, Shouri Bochetty '21

Human Diseases Graphic Novels

No abstract provided.

Sponsorship Engagement: Leveraging Ancillary Events To Increase Title Sponsor Awareness, Amanda Greene, Natalie L. Smith, Charles W. Jones

ETSU Faculty Works

No abstract provided.

Experimental Investigation Examining The Effects Of Acute Exercise On Implicit Memory Function, Paul D. Loprinzi, Morgan Gilbert, Gina Robinson, Briahna Dickerson

Faculty and Student Publications

© 2019, PsychOpen. All rights reserved. Emerging work suggests that acute exercise can enhance explicit memory function. Minimal research, however, has examined whether acute exercise is associated with implicit memory, which was the purpose of this study. Three separate experimental studies were computed (N = 120; Mean age = 21). In Experiment 1, participants were randomly assigned to either a moderate-intensity bout of acute exercise (15-minute) or engaged in a seated control task (15-minute), followed by the completion of a word-fragmentation implicit memory task. Experiment 2 replicated Experiment 1, but instead employed a higher-intensity exercise protocol. For Experiment 3, participants …

Post-Acquisition Processing Confounds In Brain Volumetric Quantification Of White Matter Hyperintensities, Ahmed A. Bahrani, Omar M. Al-Janabi, Erin L. Abner, Shoshana H. Bardach, Richard J. Kryscio, Donna M. Wilcock, Charles D. Smith, Gregory A. Jicha

Neurology Faculty Publications

BACKGROUND: Disparate research sites using identical or near-identical magnetic resonance imaging (MRI) acquisition techniques often produce results that demonstrate significant variability regarding volumetric quantification of white matter hyperintensities (WMH) in the aging population. The sources of such variability have not previously been fully explored.

NEW METHOD: 3D FLAIR sequences from a group of randomly selected aged subjects were analyzed to identify sources-of-variability in post-acquisition processing that can be problematic when comparing WMH volumetric data across disparate sites. The methods developed focused on standardizing post-acquisition protocol processing methods to develop a protocol with less than 0.5% inter-rater variance.

RESULTS: A series …

Uga Anatomy And Physiology 2 Lab Manual, 3rd Edition, Ann Massey, Lindsey Beebe, Deloris Hesse

Biological Sciences Open Textbooks

This lab manual was created for Anatomy and Physiology II at the University of Georgia under a Textbook Transformation Grant and revised through a Scaling Up OER Pilot Grant.

http://oer.galileo.usg.edu/biology-collections/12/

The manual contains the following labs:

• Blood Composition
• Blood Typing
• Heart Anatomy
• Cardiovascular Physiology
• Systemic Blood Vessels
• Anatomy of the Respiratory System
• Physiology of the Respiratory System
• Renal Anatomy
• Urinalysis
• Digestive System Anatomy
• Digestive Physiology
• Male Reproductive System
• Female Reproductive System

Accessible files with optical character recognition (OCR) and auto-tagging provided by the Center for Inclusive Design and Innovation.

The Fitness Landscape Of The African Salmonella Typhimurium St313 Strain D23580 Reveals Unique Properties Of The Pbt1 Plasmid, Rocío Canals, Roy R. Chaudhuri, Rebecca E. Steiner, Siân V. Owen, Natalia Quinones-Olvera, Melita A. Gordon, Michael Baym, Michael Ibba, Jay C. D. Hinton

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

We have used a transposon insertion sequencing (TIS) approach to establish the fitness landscape of the African Salmonella enterica serovar Typhimurium ST313 strain D23580, to complement our previous comparative genomic and functional transcriptomic studies. We used a genome-wide transposon library with insertions every 10 nucleotides to identify genes required for survival and growth in vitro and during infection of murine macrophages. The analysis revealed genomic regions important for fitness under two in vitro growth conditions. Overall, 724 coding genes were required for optimal growth in LB medium, and 851 coding genes were required for growth in SPI-2-inducing minimal medium. These …

Ankle And Midtarsal Joint Quasi-Stiffness During Walking With Added Mass, Andrew M. Kern, Nikolaos Papachatzis, Jeffrey M. Patterson, Dustin A. Bruening, Kota Z. Takahashi

Journal Articles

Examination of how the ankle and midtarsal joints modulate stiffness in response to increased force demand will aid understanding of overall limb function and inform the development of bio-inspired assistive and robotic devices. The purpose of this study is to identify how ankle and midtarsal joint quasi-stiffness are affected by added body mass during over-ground walking. Healthy participants walked barefoot over-ground at 1.25 m/s wearing a weighted vest with 0%, 15% and 30% additional body mass. The effect of added mass was investigated on ankle and midtarsal joint range of motion (ROM), peak moment and quasi-stiffness. Joint quasi-stiffness was broken …