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Mechanism Of Nitric Oxide Induced Sympatholysis In Rat Soleus Feed Arteries, Madelyn Whitaker, Jeffrey Jasperse, Tanner Heckle
Mechanism Of Nitric Oxide Induced Sympatholysis In Rat Soleus Feed Arteries, Madelyn Whitaker, Jeffrey Jasperse, Tanner Heckle
Seaver College Research And Scholarly Achievement Symposium
During exercise, the neurotransmitter norepinephrine (NE) binds to arterial adrenergic receptors to cause vasoconstriction, yet arteries and arterioles constrict less to sympathetic stimulation in contracting compared to resting skeletal muscle (sympatholysis). Previous evidence indicates that nitric oxide (NO) can be sympatholytic, but the mechanism is unknown. We hypothesized that NO causes sympatholysis in rat soleus muscle feed arteries, that NO is released from vascular endothelial cells by increased shear stress, and that NO acts through a guanylyl cyclase intracellular signaling pathway. Soleus feed arteries (n = 12 per group) were isolated from male Sprague-Dawley rats and cannulated on two glass …