Pharmacology, Toxicology and Environmental Health Commons^™

Toxicity And Mitochondrial Delivery Of Flavonol-Based Carbon Monoxide-Releasing Molecules, Hector Jose Esquer Heredia

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Despite the reputation of carbon monoxide (CO) as a silent killer, new evidence suggests that this gaseous molecule has anti-inflammatory, anti-cancer and vasoprotective properties. Unfortunately, little is known about the role of CO in the body. However, proteins present in mitochondria are believed to be important targets. We previously synthesized a class of novel and structurally modifiable flavonol-based CO-releasing molecules (CORMs). Flavonols are commonly found in fruits and vegetables. The base structure, Flav-1, is fluorescent, exhibits low toxicity, and releases CO after exposure to visible light. Previous reports indicate that addition of a triphenylphosphonium (TPP) tail allows chemical structures to …