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Full-Text Articles in Pharmacology, Toxicology and Environmental Health
An Analysis Of The Use Of Animal Models In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls
An Analysis Of The Use Of Animal Models In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls
Jarrod Bailey, PhD
Animal use continues to be central to preclinical drug development, in spite of a lack of its demonstrable validity. The current nadir of new drug approvals and the drying-up of pipelines may be a direct consequence of this. To estimate the evidential weight given by animal data to the probability that a new drug may be toxic to humans, we have calculated Likelihood Ratios (LRs) for an extensive data set of 2,366 drugs, for which both animal and human data are available, including tissue-level effects and MedDRA Level 1–4 biomedical observations. This was done for three preclinical species (rat, mouse …
Examining Infarct Sizes In Female Sprague Dawley Rats In Response To A Delayed Post-Stroke Pharmacological Treatment In Combination With Physical Rehabilitation, Sayali Ravindra Dharmadhikari
Examining Infarct Sizes In Female Sprague Dawley Rats In Response To A Delayed Post-Stroke Pharmacological Treatment In Combination With Physical Rehabilitation, Sayali Ravindra Dharmadhikari
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In this study, we hypothesize that a pharmacological drug treatment comprised of Fluoxetine, Simvastatin and Ascorbic acid together with physical rehabilitation would reduce infarct sizes. Over the period of 60 days after stroke-induction, 13 of the 23 rats were administered the drugs beginning 20-26 hours after stroke-induction and the rest were assigned to the control group. Physical rehabilitation exercises were initiated from poststroke day 8 and continued for 23 alternate days. The rats were tested for functional recovery using Montoya staircase apparatus and were euthanized after post-stroke day 60. The brains sections were analyzed using Nissl stain for infarct volume …