Pharmacology, Toxicology and Environmental Health Commons^™

Correlation Between Stress Coping Styles And Genetic Variation In The Adenosine Pathway Of Zebrafish, Sydney Klucas

Theses/Capstones/Creative Projects

Anxiety is a common mental disorder and is caused in part by dysregulation of neurotransmitter systems. Specifically, the adenosine pathway has been correlated with anxiety disorders, but it is not yet known if genetic differences in this pathway are responsible for anxiety-related behavior. In this study, I used bioinformatic analyses (EdgeR and WGCNA) to investigate an RNA-sequencing dataset to assess differences in differential gene expression and gene co-expression networks within the adenosine pathway of zebrafish with different stress coping styles. These analyses included three brain regions: basolateral amygdala, hippocampus, and habenula. The differential gene expression analysis demonstrated that the adenosine …