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Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Runx1 Loss Leads To An Epithelial To Mesenchymal Transition In Breast Cancer By Regulating Target Gene Expression., Dorcas Lohese
Runx1 Loss Leads To An Epithelial To Mesenchymal Transition In Breast Cancer By Regulating Target Gene Expression., Dorcas Lohese
Graduate College Dissertations and Theses
Breast cancer is the second leading cause of cancer death among women in the United States. Due to the various advancements in treatment, the five-year survival rate is greater than 90% among women with non-metastatic breast cancer. However, among patients with metastatic breast cancer, the five-year survival rate quickly drops to 22%. Recognizing early signs of metastasis is essential for targeting cancer before it disseminates. The epithelial-to-mesenchymal transition (EMT) is hypothesized to be a vital process for large-scale cell movement by disrupting cell-cell adhesion, allowing metastatic breast cancer cells to become more migratory. The progression of breast cancer EMT involves …
The Evaluation Of The Prokinetic Action Of A Luminally Restricted 5-Ht4 Receptor Agonist In Mice, Emma Schoeling
The Evaluation Of The Prokinetic Action Of A Luminally Restricted 5-Ht4 Receptor Agonist In Mice, Emma Schoeling
Graduate College Dissertations and Theses
Serotonin (5-HT) is a neurotransmitter mainly produced in the enteric nervous system (ENS) of the gastrointestinal (GI) system. Serotonin has widespread function throughout the body including regulating mood, cognition, sleep, sex, and appetite. In the context of the gut, the monoamine modulates vasodilation, mucus secretion, pain, and peristaltic reflexes for motility. The 5-HT4 receptor is expressed on enteric epithelial cells and nerve terminals in the intestinal mucosa. The agonists available to act on these receptors are a favorable target to promote epithelial healing, recovery from colitis or constipation, and epithelial cell proliferation. The non-absorbable, luminally restricted, 5-HT4R agonist (5HT4-LA1; Takeda …