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Layer -By -Layer Self -Assembly Of Micro-Capsules For The Magnetic Activation Of Semi-Permeable Nano-Shells, Malcolm D. Prouty
Layer -By -Layer Self -Assembly Of Micro-Capsules For The Magnetic Activation Of Semi-Permeable Nano-Shells, Malcolm D. Prouty
Doctoral Dissertations
Layer-by-layer (LbL) self-assembly has demonstrated broad perspectives for encapsulating, and the controllable delivery, of drugs. The nano-scale polymer layers have the capability of material protection. Magnetic nanoparticles have great potential to be applied with LbL technology to achieve both "focusing" of the encapsulated drugs to a specific location followed by "switching" them on to release the encapsulated drugs. In this work, Phor21-βCG(ala), dextran, and dexamethasone were used as model drugs. Encapsulation of these drugs with layer-by-layer self-assembly formed biolnano robotic capsules for controlled delivery and drug release.
Silica nanoparticles coated with polyelectrolyte layers of sodium carboxymethyl cellulose (CMC) or gelatin …