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Immunosuppression By Aflatoxin B1 In C57bl/6 Mice And Its Relationship With Neuroendocrine Mechanisms, Yasuhiko Hatori
Immunosuppression By Aflatoxin B1 In C57bl/6 Mice And Its Relationship With Neuroendocrine Mechanisms, Yasuhiko Hatori
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Aflatoxin B1 (AFB1), a secondary metabolite of Aspergillus flavus and Aspergillus parasiticus, is known for its potent carcinogenicity and immunosuppressive effects. It is also known that AFB1 toxicity appears in different degrees in different animal species and strains.
The present study was performed to reveal the involvement of the hypothalamus-pituitary-adrenal gland (HPA) axis in the immunosuppressive effects of AFB1 on C57BL/6 mice. Splenic lymphocytes were assayed to investigate their phenotyping using flow cytometry, proliferative response against mitogen and allogenic lymphocytes, cytolytic cell activity, and IL-2 production. In addition, antibody-mediated immunocompetence was checked using sheep …