Pharmacology, Toxicology and Environmental Health Commons^™

The Smell Of Hopelessness, Juline Cariba Rachel Party

Capstones

Rafts of sargassum seaweed kilometers wide have been invading the Caribbean for more than five years, but 2015 was the worst. Tons of seaweed stretch from Texas south to Trinidad and Tobago, with the Lesser Antilles suffering the most damage. Residents near beaches are exposed to an insidious and pernicious danger, scientists say, from fumes that smell like rotten eggs, emitted by the decaying algae. The odor also drives tourists away from beaches and restaurants, and the tourism economy is collapsing.Amid the algae crisis, an elderly woman, Virginie Mark, is trying to survive. She struggles with her health, finances and …

The Role Of The State, Multinational Oil Companies, International Law & The International Community: Intersection Of Human Rights & Environmental Degradation Climate Change In The 21st Century Caused By Traditional Extractive Practices, The Amazon Rainforest, Indigenous People And Universal Jurisdiction To Resolve The Accountability Issue, Marcela Cabrera Luna

Master's Theses

Local, national and international conventions that protect indigenous sovereignty and their territories, where many of the resources are extracted from by multinational corporations (MNCs) particularly oil, the number one commodity of the world and cause of climate change, continue to be jeopardized because of the lack of a clear international legal framework that can protect them and potentially hold multinationals accountable for their actions. These practices are causing not only environmental issues to the indigenous and surrounding communities, but climate change is in fact, the real human rights issue of the 21^st century and it affects everyone. By using …

Iodine-131: Measurement And Application Of A Novel Tracer In Lake Michigan, Michael Patrick Montenero

Theses and Dissertations

Iodine-131 is a short-lived (half-life=8.0233 days), gamma emitting, radiopharmaceutical that, when excreted by patients, enters aquatic systems via sewage effluent discharged from water reclamation facilities (WRFs). Here, I report on 131I activities in the nearshore of southwest Lake Michigan in the vicinity of Milwaukee, Wisconsin. This is the first report on 131I activity in any of the Great Lakes of North America.

The flux of 131I from Milwaukee’s two WRFs was monitored from July 2013 to December 2014. Mean discharge of 131I from the Jones Island WRF was (0.664 ± 0.012)×108 Bq d-1 (mean effluent 131I activity: ~0.25 Bq L-1; …

The Identification And Quantification Of Sewage Contamination In The Milwaukee Estuary, Hayley Templar

Theses and Dissertations

Sewage contamination from failing infrastructure and sewer overflows is a major environmental and human health concern in waterways, especially in urban communities bordering the Great Lakes such as Milwaukee, Wisconsin. Culture-based fecal indicator bacteria, such as Escherichia coli, enterococci, and fecal coliforms are traditionally used to indicate the presence of a human health risk due to fecal contamination. These indicators, however, fail to distinguish between sources of fecal contamination (human vs. non-human). Two human-specific fecal indicators, human Bacteroides and human Lachnospiraceae, were used to identify and quantify sewage contamination in the Milwaukee estuary, which discharges to Lake Michigan, as well …

Removal Of Trace Organic Compounds In Domestic Wastewater Using Recirculating Packed-Bed Media Filters, Brittani Nikole Perez

Masters Theses

Pharmaceuticals and personal care products (PPCPs) are commonly detected in the environment resulting from their survival from conventional wastewater treatment systems. More information is needed about the fate and transfer of these trace organic compounds in domestic wastewater and their associated risks so that efficient strategies for their removal can be developed for both large/small scale treatment systems. This study aimed to determine whether onsite wastewater treatment systems were capable of providing PPCP removal, in addition to quantifying different forms of removal (biodegradation/sorption). A column study was constructed to determine the removal efficiencies of 3 target PPCPs, endocrine disrupting compound …

Macrobenthic Communities In The Northern Gulf Of Mexico Hypoxic Zone: Testing The Pearson-Rosenberg Model, Shivakumar Shivarudrappa

Dissertations

The Pearson and Rosenberg (P-R) conceptual model of macrobenthic succession was used to assess the impact of hypoxia (dissolved oxygen [DO] ≤ 2 mg/L) on the macrobenthic community on the continental shelf of northern Gulf of Mexico for the first time. The model uses a stress-response relationship between environmental parameters and the macrobenthic community to determine the ecological condition of the benthic habitat. The ecological significance of dissolved oxygen in a benthic habitat is well understood. In addition, the annual recurrence of bottom-water hypoxia on the Louisiana/Texas shelf during summer months is well documented.

The P-R model illustrates the decreasing …

Exposure Monitoring In Developing Countries, Luis Collado

Graduate Theses & Non-Theses

Formaldehyde is widely used in the healthcare industry. Formaldehyde is used as a disinfectant and sterilant. In addition, formaldehyde/formalin is used as fixative/ preservative of anatomical specimens in pathology departments. Individuals may experience adverse effects following short term exposure above 0.1ppm. Following a laboratory study in the early 1980s, the U.S. Environmental Protection Agency (EPA) classified formaldehyde as a human carcinogen in 1987.

Although the healthcare industry in the United States made major advancement in the safe use of formaldehyde/formalin since the implementation of the Occupational Health and Safety Administration (OSHA) Formaldehyde standard, other developing countries are still struggling with …

An Investigation Of The Effect Of Malathion On Adaptive Plasticity Of Pseudacris Sierra, Michael Jonathan Maples

Master's Theses

This thesis is composed of two chapters. Chapter one reviews what is known about adaptive plasticity in response to predators, describes the physiological systems involved in such plasticity, and outlines the evolutionary consequences of adaptive plasticity. Chapter two describes a scientific experiment that investigates how malathion may impact adaptive plasticity in the Sierran Treefrog, Pseudacris sierra. Anuran tadpoles suffer high mortality rates due to predation. In response to strong selective forces relating to these high predation rates, tadpoles evolved the ability to adaptively respond to predators through morphological and behavioral plasticity. The morphological and behavioral responses are varied and depend …

Kinetic Modeling Of Catalytic Aerogels, Yi Cao

Honors Theses

As pollution becomes an increasing concern globally, strict regulations have been set on vehicle pollutant emissions. The three-way catalytic converter is capable of converting toxic emissions such as carbon monoxide, unburned hydrocarbons and nitrogen oxides to less hazardous waste such as carbon dioxide, water, and nitrogen. Current catalysts employ platinum group metals, which are expensive and environmentally damaging to mine. Catalytically-active aerogels such as Co-Al, Cu-Al and V-Al aerogels have shown promise as alternatives to these metals. The work presented here adapts and extends a global kinetic model which predicts the conversion of hydrocarbons and carbon monoxide on platinum catalyst …

Mourning Wave: Grieving The Loss Of The Natural Environment, Kayla Stewart

MAIS Projects and Theses

Informed and inspired by the sudden passing of my uncle, Mourning Wave is a physical manifestation of my own experience with grief as it relates to the natural environment. My own personal grief opened the door to experiencing collective grief. Constructed as a wave-shaped altar composed of discarded plastic, Mourning Wave aims to highlight the role of oceanic plastic debris in relation to the damage being done to the environment by humans. The wave is painted black, a traditional color of mourning. Colorful discarded plastic lies within the crest of the wave. This debris was collected several times as a …

Sem-Edx Analysis Of Aerosol Samples, Xuanhan Zhao

Honors Theses

One of the important environmental issues in upstate New York is the acid rain problem in the Adirondack Mountains, which is associated with atmospheric aerosols. As a part of a systematic study to understand the transport, transformation, and effects of airborne pollutants in the Adirondack Mountains, we are performing an analysis of atmospheric aerosols collected at Piseco Lake. In previous work, we used proton induced X-ray emission (PIXE) [1] spectrometry to measure the concentrations of elements in aerosol samples as a function of the size of the particulate matter. The results of the PIXE analysis indicate significant concentrations of sulfur …

A Geospatial Analysis Of Norovirus Outbreaks In California, And An Investigation Of The Impact Of Environmental Variables, Alexandra Groen

Master's Projects and Capstones

Previous studies and empirical evidence suggest norovirus outbreaks in California exhibit correlation with environmental variables and exhibit spatial spread patterns. Few studies have been done looking at what causes norovirus seasonality in temperate climates and more research is needed on the regional level. This study aims to find what relationships exist with outbreak occurrence and environmental variables in California, as well as any spatial patterns of spread or clustering of outbreaks. Spatial analysis tools were used to find any relationships between California norovirus outbreak data and environmental variables. The results showed a south to north spread of outbreaks in California …

Impacts Of Consumer Horticulture On Stormwater And Nutrient Management: Investigating Public Perception, Knowledge, And Practices In The Shenandoah River Watershed, Christopher P. Parker

Masters Theses, 2010-2019

The South Fork Shenandoah River is a tributary to the Chesapeake Bay that is a significant contributor to nitrogen and phosphorus that enter the Bay and leads to increased eutrophication. These nutrients also cause problems in the South Fork Shenandoah River. The United States Environmental Protection agency has implemented strict regulation to reduce nutrients entering the Bay by developing the Chesapeake Bay TMDL. While the TMDL has strict regulation on wastewater treatment, agriculture, and industry, there are still sources of nutrients entering the Bay through unregulated sources. Urban/suburban runoff is one of these sources, particularly runoff from home owner’s lawns. …

Exploring Novel Environmental Link To Obesity: Role Of Parabens In Adipogenesis In Vitro And In Vivo, Pan Hu

Doctoral Dissertations

Parabens are a group of alkyl esters of p-hydroxybenzoic acid that include methylparaben, ethylparaben, propylparaben, butylparaben, and benzylparaben. Paraben esters and their salts are widely used as preservatives in cosmetics, toiletries, food, and pharmaceuticals. Humans are exposed to parabens through the use of such products from dermal contact, ingestion, and inhalation. The extent of the exposure is reflected by the frequent detection of these compounds in urine samples in the general population. Moreover, parabens have been detected in human serum, milk, placental tissues and breast tumor tissues. Parabens have been shown to preserve estrogenic/antiandrogenic effects, and can activate peroxisome proliferator-activated …

Lead Hazard Control In Henderson, Nevada: Identifying Critical Areas And The Associated Costs, Khaye Gerazel Arcilla Rufin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Lead poisoning is a common, yet preventable childhood health problem in the United States today. Studies show statistically significant (p < .05) associations between higher childhood lead exposure and subsequent negative developmental outcomes. Since 1993, the U.S. Department of Housing and Urban Development (HUD) Lead Hazard Control (LHC) Grant Program has devoted more than $1 billion in funding to several cities.

This study investigated a total of n=75 homes enrolled into the Henderson Lead Hazard Control and Healthy Homes Program (HLHCHHP) from December 2013 – February 2015. A logistic regression was performed to ascertain the frequency of lead-based paint (LBP) found in homes based on the year it was constructed. Of the 75 enrolled and tested for LBP, 58 homes (77.3%) were found to contain LBP and 17 homes (22.7%) did not contain LBP. The significance value of p=0.013 shows that …

Determination Of The Baseline Concentration Of Mercury And Percentage Of Organic Material In Sub-Alpine Forest Soil Before Clear Cutting Within The White Mountain National Forest, Daniel Sunghoon Hong

Senior Theses and Projects

Clear-cutting has been practiced for centuries to provide timber for our societal needs. It is the most economically profitable method of timber harvesting but can create disturbances in the ecosystems when practiced irresponsibly. Clear-cutting vast parcels of land can have adverse effects on the quality of the soils, including erosion, loss of nutrients due to rapid runoff, and disruption of habitats and wildlife. Moreover, with large parcels of trees cut, soils are more exposed to direct airborne fallout and rapid runoff of trace metals such as mercury (Hg) into nearby fluvial systems. In the summer of 2013, soil samples were …

Role Of Caveolin-1 And Nrf2 In Nutritional Modulation Of Pcb Toxicity, Michael C. Petriello

Theses and Dissertations--Toxicology and Cancer Biology

Cardiovascular disease is the leading cause of mortality in Western societies and is linked to multiple modifiable risk factors including lifestyle choices. Emerging evidence implicates exposure to persistent environmental pollutants, such as polychlorinated biphenyls (PCBs), as a risk factor for the development or progression of cardiovascular disease. To reduce disease risks, it is critical to identify sensible means of biomedically reducing the toxicity of persistent organic pollutants and related environmental stressors.

First, we tested a hypothesis that endothelial cell inflammation and subsequent cardiovascular toxicity initiated by coplanar PCBs is modulated by the crosstalk between caveolae and Nuclear factor (erythroid-derived 2)-like …

Effects Of The Deepwater Horizon Oil Spill On Deep Sea Fishes, Arianne Ella Leary

UNF Graduate Theses and Dissertations

The Deepwater Horizon Oil Spill (DWH) released about 4.4 million barrels of crude oil into the Gulf of Mexico (GOM), making it one of the largest oil spills in U.S. history. Additionally, the depth of the spill (i.e., 1500 meters) created a unique research opportunity because most oil spills occur at the surface and affect coastal rather than deepwater habitats. Polycyclic aromatic hydrocarbons (PAHs) are the most toxic components of oil, and are often the focus of oil exposure studies. PAHs are quickly metabolized by vertebrates; therefore, indicators of biological responses to PAH exposure (PAH “biomarkers”) such as the levels …

Ten Weeks With Green Beans...And Then Some: Determination Of Bisphenol-A (Bpa) In Canned Goods From Arkansas Markets Using Fluorescence Spectrophotometry, Rachel Pruett

Honors Theses

Bisphenol A (BPA) is a chemical widely used in production of consumer goods. It has come under scrutiny recently after being labeled as an endocrine disruptor (ED), mostly causing adverse effects in infants and young children. It has been associated with diabetes, cardiovascular disease, and abnormal maturation. Because it is so commonly used in product development, humans are exposed to BPA through various means, such as ingestion or dermal absorption. It is a concern that the combined exposure could cause serious effects even in small doses.

In canned foods, the chemical is made into an epoxy resin to provide a …

Detecting Diesel Particulate Matter Using Real Time Monitoring Under The Influence Of An Exhaust Fan System, Yasir Helal Alghamdi

Masters Theses

"Diesel Particulate Matter (DPM) is a complex mixture of diesel exhaust gas that consists of carbon, ash, metallic abrasion particles, sulfates and silicates. The diesel soot particle includes a solid core made of elemental carbon, and organic carbon compound attached to the surface of the soot particle. The main source of DPM is diesel exhaust gas. The National Institute for Occupational Safety and Health (NIOSH) and the Environmental Protection Agency (EPA) have determined that DPM is the source of most of the emissions of carbon monoxide, carbon dioxide, oxide of nitrogen, and hydrocarbons in underground coal, metal and non metal …

Study Of Human Ovarian Follicular Fluid High Density Lipoprotein (Hdl) And Embryo Quality During In Vitro Fertilization (Ivf), Keewan Kim

Legacy Theses & Dissertations (2009 - 2024)

Follicular fluid (FF) is in direct contact with granulosa cells that surround a developing oocyte, and high density lipoprotein (HDL) is the sole lipoprotein found in FF. Therefore, we investigated 41 FF HDL particle components, including 26 HDL-cholesterol (HDL-C) subfractions measured for particle size, apolipoproteins, enzymes, and lipophilic micronutrients, in association with embryo quality on 180 women undergoing in vitro fertilization (IVF).

Nutrient Availability And Dynamics Of Compost Bedded Pack Dairy Barn Waste, Leslie Hammond

Theses and Dissertations--Plant and Soil Sciences

Increased adoption of compost bedded pack dairy barns (CBP), a relatively new housing and manure handling strategy, warrants study to facilitate proper use of CBP waste as a soil amendment. This study: 1) characterized in situ nutrient content and availability of CBP waste in terms of nitrogen (N) and phosphorus (P); 2) examined the decomposition of surface-applied CBP waste compared to an alternative processed solid waste amendment; 3) examined nutrient dynamics of incorporated CBP waste in high and low soil test phosphorus (STP) environments. Quick anaerobic mineralization assays revealed that bed management affects nutrient content and availability of CBP waste. …

Bacterial Communication And Its Role As A Target For Nanoparticle-Based Antimicrobial Therapy, Kristen Publicover Miller

Theses and Dissertations

The goal of this dissertation is to establish the environmental and public health importance of alternative forms of antimicrobial therapy, specifically those that utilize nanotechnology to combat quorum sensing-controlled bacterial infections. Quorum sensing (i.e. chemical communication) is an inherent characteristic that is essential to bacterial pathogenesis and biofilm formation (where most infections occur). A thorough review of the literature has been conducted to establish an understanding of the state of nanotechnology research as it relates to combatting bacterial infections. This synthesis, provided in Chapter 1, demonstrates how the chemical and structural designs of nanoparticles can be manipulated to specifically target …

High-Content Screening In Zebrafish Embryos Identifies Abamectin As A Potent Neurotoxicant, Tara Diane Raftery

Theses and Dissertations

During development, the nervous system is a sensitive target for chemical exposure in both humans and animal models, and early life-stage exposures can lead to long-term effects on motor activity, sensory function, and cognition. Currently, there are minimal to no developmental neurotoxicity (DNT) data available for thousands of chemicals used in commerce, and it is impractical to screen these chemicals in rodent models using the existing DNT test guideline, as this test is costly, time- and animalintensive, and low-throughput. Therefore, there is a recognized need to use alternative non-mammalian models to support screening and prioritization of chemicals for DNT testing, …