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Pharmacology, Toxicology and Environmental Health Commons™
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- Angiogenesis (2)
- Aminoacyl tRNA synthetase (1)
- Aminoacyl-tRNA Synthetase (1)
- ER stress (1)
- Endothelial Cells (1)
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- Enzyme Inhibition (1)
- Exosome (1)
- Eye Blink Conditioning (1)
- GRM1 (1)
- Glutamate receptors (1)
- Glycogen metabolism (1)
- KCNA2 (1)
- Non-canonical Function (1)
- Ovarian cancer (1)
- PI3K signaling (1)
- PKC (1)
- Polyketide (1)
- Targeted therapy (1)
- Threonyl tRNA synthetase (TARS) (1)
- Thyroid cancer (1)
- Thyroid hormone receptor (1)
- Voltage gated potassium channels (1)
Articles 1 - 4 of 4
Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Thyroid Hormone Receptor Beta Inhibits Pi3k Signaling And Glycogen Metabolism In Anaplastic Thyroid Cancer, Cole Davidson
Thyroid Hormone Receptor Beta Inhibits Pi3k Signaling And Glycogen Metabolism In Anaplastic Thyroid Cancer, Cole Davidson
Graduate College Dissertations and Theses
Thyroid cancer is the most common endocrine malignancy, and the global incidence has increased rapidly over the past few decades. While differentiated thyroid cancers often respond to standard therapies, there are no durable long-term treatment options for anaplastic thyroid cancer (ATC). The limited treatment options highlight a need for a deeper understanding of the molecular signaling in these aggressive tumors for development of more effective therapies.Non-steroidal nuclear receptors, such as thyroid hormone receptors (TRs), are an emerging class of therapeutic targets and tumor suppressors in thyroid and other cancers.Loss of expression of the tumor suppressor thyroid hormone receptor beta (TRβ) …
The Metabotropic Glutamate Receptor Mglur1 Regulates The Voltage-Gated Potassium Channel Kv1.2 Through Agonist-Dependent And Agonist-Independent Mechanisms, Sharath Chandra Madasu
The Metabotropic Glutamate Receptor Mglur1 Regulates The Voltage-Gated Potassium Channel Kv1.2 Through Agonist-Dependent And Agonist-Independent Mechanisms, Sharath Chandra Madasu
Graduate College Dissertations and Theses
The voltage gated potassium channel Kv1.2 plays a key role in the central nervous system and mutations in Kv1.2 cause neurological disorders such as epilepsies and ataxias. In the cerebellum, regulation of Kv1.2 is coupled to learning and memory. We have previously shown that blocking Kv1.2 by infusing its specific inhibitor tityustoxin-kα (TsTX) into the lobulus simplex of the cerebellum facilitates eyeblink conditioning (EBC) and that EBC itself modulates Kv1.2 surface expression in cerebellar interneurons. The metabotropic glutamate receptor mGluR1 is required for EBC although the molecular mechanisms are not fully understood. Here we show that infusion of the mGluR1 …
Changes In Threonyl-Trna Synthetase Expression And Secretion In Response To Endoplasmic Reticulum Stress By Monensin In Ovarian Cancer Cells, Jared Louis Hammer
Changes In Threonyl-Trna Synthetase Expression And Secretion In Response To Endoplasmic Reticulum Stress By Monensin In Ovarian Cancer Cells, Jared Louis Hammer
Graduate College Dissertations and Theses
Aminoacyl-tRNA synthetases (ARS) are a family of enzymes that catalyze the charging of amino acids to their cognate tRNA in an aminoacylation reaction. Many members of this family have been found to have secondary functions independent of their primary aminoacylation function. Threonyl-tRNA synthetase (TARS), the ARS responsible for charging tRNA with threonine, is secreted from endothelial cells in response to both vascular endothelial growth factor (VEGF) and tumor necrosis factor-α (TNF-α), and stimulates angiogenesis and cell migration. Here we show a novel experimental approach for studying TARS secretion, and for observing the role of intracellular TARS in the endoplasmic reticulum …
Characterization Of A Non-Canonical Function For Threonyl-Trna Synthetase In Angiogenesis, Adam Christopher Mirando
Characterization Of A Non-Canonical Function For Threonyl-Trna Synthetase In Angiogenesis, Adam Christopher Mirando
Graduate College Dissertations and Theses
In addition to its canonical role in aminoacylation, threonyl-tRNA synthetase (TARS) possesses pro-angiogenic activity that is susceptible to the TARS-specific antibiotic borrelidin. However, the therapeutic benefit of borrelidin is offset by its strong toxicity to living cells. The removal of a single methylene group from the parent borrelidin generates BC194, a modified compound with significantly reduced toxicity but comparable anti-angiogenic potential. Biochemical analyses revealed that the difference in toxicities was due to borrelidin's stimulation of amino acid starvation at ten-fold lower concentrations than BC194. However, both compounds were found to inhibit in vitro and in vivo models of angiogenesis at …