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Pharmacology, Toxicology and Environmental Health Commons

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Full-Text Articles in Pharmacology, Toxicology and Environmental Health

Analysis And Identification Of Phenolic Compounds With Antiproliferative Activity From Chinese Olive (Canarium Album L.) Fruit Extract By Hplc-Dad-Spe-Tt-Nmr, Yu-Te Yeh, Chien-Kuang Chen, Yi-Chun Liao, Shoei-Sheng Lee, Shu-Chen Hsieh Dec 2023

Analysis And Identification Of Phenolic Compounds With Antiproliferative Activity From Chinese Olive (Canarium Album L.) Fruit Extract By Hplc-Dad-Spe-Tt-Nmr, Yu-Te Yeh, Chien-Kuang Chen, Yi-Chun Liao, Shoei-Sheng Lee, Shu-Chen Hsieh

Journal of Food and Drug Analysis

Chinese olives (Canarium album L.) are rich in phenolic compounds, exhibiting a broad spectrum of potential clinical applications. This study is the first report on the isolation and elucidation of bioactive compounds with high antiproliferative activity from the ethyl acetate fraction of a Chinese olive fruit methanolic extract (CO-EtOAc). We used the WST-1 assay to determine which subfractions of CO-EtOAc had significant antiproliferative activity using the murine colon cancer cell line CT26. Subsequently, the functional compounds were characterized by the hyphenated technique and high-performance liquid chromatography-diode array detector-solid phase extraction-transfer tube-nuclear magnetic resonance (HPLC-DAD-SPE-TT-NMR). Thirteen phenolic constituents were identified …


Antioxidant Potential Of Wild Lagenaria Siceraria (Molina) Standl, Suraj B. Patel, Usmangani A. Attar, S G. Ghane Jan 2018

Antioxidant Potential Of Wild Lagenaria Siceraria (Molina) Standl, Suraj B. Patel, Usmangani A. Attar, S G. Ghane

The Thai Journal of Pharmaceutical Sciences

Objective: The aim of the present study was to evaluate the phytochemicals and antioxidant activity of leaf and fruit of wild Bottle gourd. Methods: Successive extraction of dried material was done by soxhlet apparatus and phytochemicals such as total p..


Investigating The Toxicity And Accumulation Of 2,4-Dichlorophenoxyacetic Acid (2,4-D) And Glyphosate In Eisenia Fetida, Caitlin Lazurick, Nicole Lidzbarski, Rachel Owings, Jeff Brotherton, Edna Steele Nov 2017

Investigating The Toxicity And Accumulation Of 2,4-Dichlorophenoxyacetic Acid (2,4-D) And Glyphosate In Eisenia Fetida, Caitlin Lazurick, Nicole Lidzbarski, Rachel Owings, Jeff Brotherton, Edna Steele

Journal of the South Carolina Academy of Science

Glyphosate, the main ingredient in Roundup®, is the most widely used herbicide in the world. It is also used in combination with another effective herbicide, 2,4-D, in the formulation called Enlist Duo®. The EPA approved the use of Enlist Duo® on certain crops including those genetically modified to be resistant to both herbicides. The predicted significant increase in the use of these herbicides raised concerns from the general public because both compounds have been classified as possibly or probably carcinogenic. Since herbicides are applied directly to vegetation, the safety of organisms that come in contact …


Uncoupling Of Mitochondrial Oxidative Phosphorylation By Ancistrotectorine(การอันคัปปลิงของกระบวนการออกสิเดทีฟ ฟอสฟอริลเลซัน ของไมโตคอนเ..., Wiboon Wattanatorn, Nijsiri Ruangrungsi, Withaya Janthasoot Jan 1992

Uncoupling Of Mitochondrial Oxidative Phosphorylation By Ancistrotectorine(การอันคัปปลิงของกระบวนการออกสิเดทีฟ ฟอสฟอริลเลซัน ของไมโตคอนเ..., Wiboon Wattanatorn, Nijsiri Ruangrungsi, Withaya Janthasoot

The Thai Journal of Pharmaceutical Sciences

Ancistrotectorine, a new alkaloid from Ancistrocladus tectorius, was found to possess uncoupling activity on isolated rat liver mitochondria. This compound stimulated state 4 respiration and consequently reduced respiratory control index and ADP/O ratio ...


The Evaluation Of Minoxidil Stability Through Physical Observation Method.(การประเมินความคงตัวของไมนอกซิดิล โดยวิธีสังเกตทางกายภาพ), พิมลพรรณ พิทยานกุล Jan 1988

The Evaluation Of Minoxidil Stability Through Physical Observation Method.(การประเมินความคงตัวของไมนอกซิดิล โดยวิธีสังเกตทางกายภาพ), พิมลพรรณ พิทยานกุล

The Thai Journal of Pharmaceutical Sciences

This report presents the results from the studies of the evaluation of minoxidil stability in ethanol, propylene glycol and in the forms of pharmacceutical preparations particularly hydroalcoholic lotion and hydroalcoholic gel. Loniten® and minoxidil, p...