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Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Evaluating A Novel Photochemical Tool For Labeling And Tracking Live, Endogenous Calcium-Permeable Ampars, Rosamund Elizabeth Combs-Bachmann
Evaluating A Novel Photochemical Tool For Labeling And Tracking Live, Endogenous Calcium-Permeable Ampars, Rosamund Elizabeth Combs-Bachmann
Masters Theses
The purpose of this research is to advance development of a photochemical tool designed to probe the role of ionotropic glutamate receptor signaling in neurodegenerative processes, and to delve more deeply into the biological processes underlying the role of these receptors in signaling and memory formation. This ligand-targeted nanoprobe was designed and developed in our lab to label endogenous calcium-permeable AMPARs (CP-AMPARs) in live cells with minimal disruption to native receptor activity. Nanoprobe is designed to use naphthyl acetyl spermine (NASPM) as a photocleavable ligand to target and covalently label native CP-AMPARs with a non-perturbing, fluorescent marker that then allows …
Artificial Neural Network Approach To Predict Blast-Induced Ground Vibration, Airblast And Rock Fragmentation, Raymond Ninnang Tiile
Artificial Neural Network Approach To Predict Blast-Induced Ground Vibration, Airblast And Rock Fragmentation, Raymond Ninnang Tiile
Masters Theses
"Blasting has been widely used as an economical and cheap way of rock breakage in mining and civil engineering applications. An optimal blast yields the best fragmentation in a safe, economic and environmentally friendly manner. The degree of fragmentation is vital as it determines to a large extent the utilization of equipment, productivity and mill throughput. Explosive energy, besides rock fragmentation, creates health and safety issues such as ground vibration, air blast, fly rock, and back breaks among others. As a result, the explosive energy impacts structures and buildings located in the vicinity of the blasting operation, and causes human …