Pharmacology, Toxicology and Environmental Health Commons^™

Pharmacokinetic Assessment Of The Influence Of Dietary Fiber On The Absorption And Disposition Of Selected Model Xenobiotics As It Relates To Colon Cancer, Joseph Donald Debethizy

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Selected drugs are being utilized as models of putative colon carcinogens in a study of the influence of major types of dietary fiber upon drug pharmacokinetics. Adult, male Wistar rats were pretreated with standardized, isocaloric hydrated gelatin diets containing no fiber or 15% (w/w) cellulose, lignin, hemicellulose (metamucil), or pectin for 30 days. An additional group was fed lab chow ad libitum as a reference control.

The pharmacokinetics of acetaminophen, FD & C Red No. 2 and mirex were examined following oral administration in three separate experiments. Among fiber types, pectin and hemicellulose (Metamucil) caused higher peak plasma concentrations of …

Pesticide Exposure Studies: Direct And Indirect Detection Of Absorption Of 2,4-D And Pronamide Herbicides In The Guinea Pig And Occupationally Exposed Workers, Ibrahim A.R. Al-Jabery

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A simple high pressure liquid chromatography procedure was used to determine 2,4-D and pronamide exposure in spraymen and their dermal absorption and excretion in guinea pigs.

Results of dermal application of these herbicides to guinea pigs demonstrated a strong correlation between the applied dermal dose and the urinary residue excretion over the dosage range tested. As the dosage was increased, the urinary excretion of residues was also increased. However, the excretion of 2,4-D amine mixture following dermal treatment of guinea pigs was prolonged as compared to that of pronamide.

Residue levels of these compounds were also determined to estimate skin …

Absorption, Translocation And Metabolism Of 1,3-Dichloropropene In Selected Plants, David L. Berry

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The absorption, translocation and metabolism of 1,3-dichloropropene (a soil fumigant) in bush beans, tomato and carrot was studied under growth chamber and greenhouse conditions using solution culture, vermiculite and sand. Absorption was monitored using gas chromatographic analysis and isotope techniques. Plants were shown to absorb a maximum amount of dichloropropene by 24 to 48 hr from solution culture and vermiculite. The plant absorbed and translocated 1,3-dichlorpropene-¹⁴C-U readily to aerial parts of the plant.

Bush beans, tomatoes and carrots absorbed and translocated 3-chlorallyl alcohol-¹⁴C-U from solution culture and vermiculite. Levels of 3-chloroallyl alcohol reached maximum at 24 …