Pharmacology, Toxicology and Environmental Health Commons^™

Pathophysiology Of Hemorrhagic Shock And The Protective Effects Of Antioxidants, Annette Elizabeth Fleckenstein

Masters Theses

Considerable attention has focused on the role of free radicals in the pathophysiology of hemorrhagic shock. In this study, four pharmacological mechanisms for antagonizing free radical generation or reactions were compared in terms of their efficacy in attenuating post-hemorrhage (post-reinfusion) cardiovascular collapse. These included blocking arachidonic acid oxidation by cyclooxygenase (eg; ibuprofen), inhibiting superoxide radical production by xanthine oxidase (eg; oxypurinol), chelating iron (eg; desferal), and inhibiting lipid peroxidation (eg; U74006F and U78517G, Upjohn Company, Kalamazoo, Michigan).

Cardiovascular function, cerebral blood flow, arterial blood gases, serum glucose, and plasma vitamin E were examined in a hemorrhage/reperfusion model using urethane-anesthetized rats. …