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Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Interactions Between Soft Nanoparticles And Mammalian Cells, Mitchell Raith
Interactions Between Soft Nanoparticles And Mammalian Cells, Mitchell Raith
Doctoral Dissertations
Nanoparticles have been of interest to the pharmaceutical industry since the 1980s. The first FDA approved nanoparticle-based therapies included liposomal anesthesia agents. Since then, the amount of FDA-approved nanoparticle therapies remains low. This is because nanoparticle-patient interactions can be very complex and are not well understood. Complicating factors also include increasing obesity rates among the patient population and many small animal pre-clinical trials are completed with healthy, lean animals. The biochemical differences between lean and obese patients prevents early studies from accurately predicting nanoparticle clinical behaviors. Many nanoparticles fail in trails. In this thesis, I aimed to uncover how nanoparticles …
Buprenorphine Effects On Anxiety-Like Behavior In B6 Mice, Megan K. Thibert
Buprenorphine Effects On Anxiety-Like Behavior In B6 Mice, Megan K. Thibert
Select or Award-Winning Individual Scholarship
Buprenorphine, a semi-synthetic opioid prescribed for the treatment of opioid use disorder (OUD), has been suggested as a potential pharmacological treatment for anxiety. Some preclinical and clinical studies provide support for the anxiolytic effects of buprenorphine, but research in this area is scarce, and findings to date have been mixed. The present study was designed to test the hypothesis that buprenorphine alters anxiety-like behavior in C57BL/IJ (B6) mice measured using the elevated zero maze (EZM). Adult, male mice (n=10) were given subcutaneous injections of saline (control) and three doses of buprenorphine (0.3, 1, and 10 mg/kg). One hour following injection, …