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Pharmacology, Toxicology and Environmental Health Commons

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Full-Text Articles in Pharmacology, Toxicology and Environmental Health

A Balance Between Inhibitor Binding And Substrate Processing Confers Influenza Drug Resistance, Li Jiang, Ping Liu, Claudia Bank, Nicholas Renzette, Kristina Prachanronarong, L. Yilmaz, Daniel Caffrey, Konstantin Zeldovich, Celia Schiffer, Timothy Kowalik, Jeffrey Jensen, Robert Finberg, Jennifer Wang, Daniel Bolon Jan 2016

A Balance Between Inhibitor Binding And Substrate Processing Confers Influenza Drug Resistance, Li Jiang, Ping Liu, Claudia Bank, Nicholas Renzette, Kristina Prachanronarong, L. Yilmaz, Daniel Caffrey, Konstantin Zeldovich, Celia Schiffer, Timothy Kowalik, Jeffrey Jensen, Robert Finberg, Jennifer Wang, Daniel Bolon

Celia A. Schiffer

The therapeutic benefits of the neuraminidase (NA) inhibitor oseltamivir are dampened by the emergence of drug resistance mutations in influenza A virus (IAV). To investigate the mechanistic features that underlie resistance, we developed an approach to quantify the effects of all possible single-nucleotide substitutions introduced into important regions of NA. We determined the experimental fitness effects of 450 nucleotide mutations encoding positions both surrounding the active site and at more distant sites in an N1 strain of IAV in the presence and absence of oseltamivir. NA mutations previously known to confer oseltamivir resistance in N1 strains, including H275Y and N295S, …


A Cluster-Based Approach For Biological Hypothesis Testing And Its Application, Ahmed Mustafa Jun 2012

A Cluster-Based Approach For Biological Hypothesis Testing And Its Application, Ahmed Mustafa

Ahmed Mustafa Dr.

No abstract provided.


Effects Of Capsaicin Supplemented Feed On The Growth And Immune Response Of Coho Salmon, Oncorhynchus Kisutch., Ahmed Mustafa, Paul Mccain, Devin Carr Dec 2011

Effects Of Capsaicin Supplemented Feed On The Growth And Immune Response Of Coho Salmon, Oncorhynchus Kisutch., Ahmed Mustafa, Paul Mccain, Devin Carr

Ahmed Mustafa Dr.

No abstract provided.


Effects Of Vitamin C On Expression Of Stress Genes In Tilapia, Oreochromis Niloticus., Ahmed Mustafa, Sharif Hayat, Jessica Eash Dec 2011

Effects Of Vitamin C On Expression Of Stress Genes In Tilapia, Oreochromis Niloticus., Ahmed Mustafa, Sharif Hayat, Jessica Eash

Ahmed Mustafa Dr.

No abstract provided.


Survey Of Antibiotic Resistant Bacteria In Fish Gut Collected From Selected Sites., Ahmed Mustafa, Hasina Karki, Arlis Lamaster, Bob Gillespie, Shree Dhawale Dec 2011

Survey Of Antibiotic Resistant Bacteria In Fish Gut Collected From Selected Sites., Ahmed Mustafa, Hasina Karki, Arlis Lamaster, Bob Gillespie, Shree Dhawale

Ahmed Mustafa Dr.

No abstract provided.


Effects Of Capsaicin Supplemented Feed On The Growth And Immune Response Of Tilapia, Oreochromis Niloticus, Ahmed Mustafa, Paul Mccain, Devin Carr Dec 2011

Effects Of Capsaicin Supplemented Feed On The Growth And Immune Response Of Tilapia, Oreochromis Niloticus, Ahmed Mustafa, Paul Mccain, Devin Carr

Ahmed Mustafa Dr.

No abstract provided.


Psychology (Addiction: Biology, Psychology And Society), Ahmed Mustafa, Sharon Morgillo, Shree Dhawale Dec 2011

Psychology (Addiction: Biology, Psychology And Society), Ahmed Mustafa, Sharon Morgillo, Shree Dhawale

Ahmed Mustafa Dr.

No abstract provided.


Effects Of Indian Herbs On The Modulation Of Stress And Immune Response In Tilapia., Ahmed Mustafa, Brittany Byerley, Paul Mccain Dec 2010

Effects Of Indian Herbs On The Modulation Of Stress And Immune Response In Tilapia., Ahmed Mustafa, Brittany Byerley, Paul Mccain

Ahmed Mustafa Dr.

No abstract provided.


Effects Of Dietary Supplementation Of The Acidifier Vitoxal-Mionix On Growth, Survival, Immune Response And Gut Microbiota Of The Pacific White Shrimp, Litopenaeus Vannamei, Ahmed Mustafa, Davies Anuta, Alehandro Buentello, Susmita Patnaik, Addison Lawrence, Michaele Hume, Delbert Gatlin, Maurice Kemp Dec 2010

Effects Of Dietary Supplementation Of The Acidifier Vitoxal-Mionix On Growth, Survival, Immune Response And Gut Microbiota Of The Pacific White Shrimp, Litopenaeus Vannamei, Ahmed Mustafa, Davies Anuta, Alehandro Buentello, Susmita Patnaik, Addison Lawrence, Michaele Hume, Delbert Gatlin, Maurice Kemp

Ahmed Mustafa Dr.

No abstract provided.


Effects Of Indian Herbs On The Modulation Of Stress And Immune Response In Tilapia., Ahmed Mustafa, Brittany Byerley, Hasina Karki Dec 2010

Effects Of Indian Herbs On The Modulation Of Stress And Immune Response In Tilapia., Ahmed Mustafa, Brittany Byerley, Hasina Karki

Ahmed Mustafa Dr.

No abstract provided.


Feasibility Of Farming Nile Tilapia, Oreochromis Niloticus (L.), In Suboptimal Water Temperature, Ahmed Mustafa, Laura Randolph, Shree Dhawale Dec 2010

Feasibility Of Farming Nile Tilapia, Oreochromis Niloticus (L.), In Suboptimal Water Temperature, Ahmed Mustafa, Laura Randolph, Shree Dhawale

Ahmed Mustafa Dr.

No abstract provided.


Effects Of Indian Herbs On The Modulation Of Stress And Immune Response In Tilapia, Ahmed Mustafa, Brittany Byerley, Paul Mccain Dec 2010

Effects Of Indian Herbs On The Modulation Of Stress And Immune Response In Tilapia, Ahmed Mustafa, Brittany Byerley, Paul Mccain

Ahmed Mustafa Dr.

No abstract provided.


Sustainable Brackish Water Shrimp Farming – A Serious Thought In India., Ahmed Mustafa, Maryam Moshref, Susmita Patnaik Dec 2006

Sustainable Brackish Water Shrimp Farming – A Serious Thought In India., Ahmed Mustafa, Maryam Moshref, Susmita Patnaik

Ahmed Mustafa Dr.

No abstract provided.


Iodinated Feed Reduces Stress In Steelhead Trout., Ahmed Mustafa Dec 2002

Iodinated Feed Reduces Stress In Steelhead Trout., Ahmed Mustafa

Ahmed Mustafa Dr.

No abstract provided.