Pharmacology, Toxicology and Environmental Health Commons^™

Towards Gene Therapy Of Parkinson’S Disease: Implantation Of Ruc-Gdnf Secreting Mammalian Cell Lines Into Rat Brain, Hua Liu

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study is to develop a new approach for monitoring the function of implanted cells by a Renilla luciferase -glial cell line derived neurotrophic factor (RUC-GDNF) fusion protein in CSF. The RUC-GDNF protein is expected to report GDNF secreted from the cell by bioluminescence through luciferase activity.

Current ex vivo gene therapy using GDNF is limited by lack of a monitoring mechanism to determine the expression of GDNF once transformed cells or vector DNA are injected into animal models. Since the therapeutic concentration of GDNF secreted into cerebrospinal fluid (CSF) by implanted cells is too low for …

Mechanisms Of Calcium Buffering And Aging In Neurons: Testing The Limits Of Homeostasis, William James Pottorf Ii

Loma Linda University Electronic Theses, Dissertations & Projects

Intracellular calcium ([Ca²⁺]i) is an ubiquitous second messenger that integrates multiple and diverse neuronal pathways that include development and maturation, gene expression, synaptic plasticity, transmitter release, excitability, and even cell death. Upon neuronal excitation the [Ca²⁺]i increases rapidly and the calcium buffering system reacts quickly to restore [Ca²⁺]i to basal levels in order to reset the cell for the next stimulus and avoid prolonged exposure to cytotoxic levels of high [Ca²⁺]i. The aging process appears to causes multiple changes in the ability of neurons to regulate [Ca²⁺]i homeostasis and an …

Investigations On The Use Of Ion Mobility Spectrometry For Clinical Chemistry Applications, Henri Parson Patten

Theses and Dissertations in Biomedical Sciences

The major objective of this research is to examine ion mobility spectrometry as a rapid screening tool for specific application to clinical chemistry research and laboratory use. Methodology was developed for target analytes representing several classes of physiologically active substances, including anesthetics, illicit drugs, and their metabolites. The IMS characteristics of animal tissues and other compounds such as amino acids and proteins were determined. Quality assurance and control procedures were developed for specific quality data objectives. Criteria were established relating to use of IMS for assessing the precision and accuracy of data, qualitative screening, and semi-quantitative analyses.

It was found …

Polycythemia Of Newborn Infant : Normal Saline Partial Exchange Transfusion(ภาวะเลือดขนในเด็กแรกเกิด : การเปลี่ยนถ่ายเลือดบางส่วนด้วย นํ้า..., Petcharindr Yamarat, Suparach Karnjanavanich

The Thai Journal of Pharmaceutical Sciences

Polycythemia can cause abnormalities in many systems such as nervous system, cardiovascular system and pulmonary system. The standard treatment for polycythemia is plasma partial exchange transfusion. However, the use of blood and components of blood in ...

Key Word Index, Author Index(ดรรชนีกุญแจคำ, ดรรชนีผู้แต่ง), N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Newborn Porcine Skin As A Model Membrane For In Vitro Percutaneous Absorption(การใช้หนังสุกรเป็นแบบจำลองของการดูดซึมผ่านผิวหนัง), Tanasait Ngawhirunpat, Suwannee Panomsuk, Praneet Opanasopit, Sayan Junsook, Supapom Pompinatepong

The Thai Journal of Pharmaceutical Sciences

The ill vitro skin permeation of six hydrophilic drugs (1-dopa, nicorandil, antipyrine, 5- fluorouracil, diclofenac sodium and dopamine hydrochloride) and six lipophilic drugs (ketoprofen, isosorbide dinitrate, indomethacin, ibuprofen, flurbiprofen and c...

Keyword Index, Author Index (ดรรชนีกุญแจคำ, ดรรชนีผู้แต่ง), N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Modulation Of The Pharmacokinetics And Pharmacodynamics Of Proteins By Polyethylene Glycol Conjugation, Reza Mehvar

Pharmacy Faculty Articles and Research

With the rapid advances in the field of biotechnology during the last decade, many peptides and proteins have been produced and evaluated for therapy of various diseases, including cancer. However, rapid clearance and the possibility of immunogenicity after the in vivo administration of these biotechnology-driven products have impeded their marketing. To circumvent these problems, synthetic and natural polymers such as polyethylene glycol (PEG) and dextrans, respectively, have been covalently attached to proteins, and some of these protein-polymer conjugates have shown promising therapeutic results. The conjugation of proteins with polymers usually causes a reduction in the recognition of the protein by …

Relicensing: Are Thai Pharmacists Ready?(การต่ออายุใบอนุญาตประกอบวิชาชีพ: เภสัชกรพร้อมหรือยัง), Sauwakon Ratanawijitrasin, Sawat Seega, Sirikwan Loongban

The Thai Journal of Pharmaceutical Sciences

Resolutions of the Thai Pharmaceutical Council in February and March 1998 set to institute a relicensing system for Thai pharmacists with continuing education as its requirement. A study was conducted between October 1998 and January 1999 to survey the o...

Chiral Liquid Membrane Containinga Dipentyl-P-Cyclodextrin : Enantioselective Partition Of Racemic Pseudoephedrine(ไครัลลิควิดเมมเบรนที่มีไดเพนทิลบีต้าใซโคลเด็กต..., Teerapol Srichana, Roongnapa Suedee

The Thai Journal of Pharmaceutical Sciences

This study was designed to examine enantioselective transport of pseudoephedrine through a two phase and chiral liquid membrane containing heptakis (di-o-pentyl)-P-cyclodextrin (dipentyl-P-CD). The molar ratio of dipentyl-P-CD to pseudoephedrine and pH o...

Enantiomeric Separation Of Salbutamol From Spiked Urine Extracted With Solid Stationary Phase(การแยกอิแนนทิโอเมอร์ของ Salbutamol ที่เติมในตัวอย่างปัสสาวะโด..., Teerapol Srichana, Roongnapa Suedee

The Thai Journal of Pharmaceutical Sciences

A solid phase extraction procedure followed by a fluorescence HPLC assay was developed for the determination of salbutamol enantiomers in urine. The extraction method employing silica cartridge made in house, was proved to be able to eliminate the matrix...

Self-Efficacy And Nonadherence In Post Renal Transplant Patients(ความมั่นใจในสมรรถนะของตนกับการไม่ใช้ยาตามสั่งในผู้ป่วยหลังผ่าตั..., Titinun Auamnoy, Bernard Sorofman, John Bertolatus, John Brooks, William Doucette, David Min

The Thai Journal of Pharmaceutical Sciences

This study investigated health behaviors in post renal transplant patients to examine the correlation between Self-efficacy (confidence in one's readiness to perform a specific thing in a specific situation) and adherence to medical regimens. Our purpos...

Efficacy And Safety Of Once-Daily Versus 12-Hour Dosing Of Amikacin In Thai Children At Queen Sirikit National Institute Of Child Health(ประสิทธิผลและความปลอดภัยของการให้ยาอะมิ..., Jutamat Titipankul, Wanchai Treyaprasert, Nans Waranawat

The Thai Journal of Pharmaceutical Sciences

The objective of this study was to compare the serum level, efficacy and nephrotoxicity of amikacin administrated as once-daily dosing versus every 12-hour dosing in pediatric patients at Queen Sirikit National Institute of Child Health (The Children Hos...

Methicillin Resistance In Coagulase-Negative Staphylococci(การดื้อยา Methicillin ในเชื้อพวก Coagulase-Negative Staphylococci), Mali Wirotesangthong, Pintip Pongpech

The Thai Journal of Pharmaceutical Sciences

To investigate prevalence of methicillin-resistant, coagulase- negative staphylococci (MRCoNS), CoNS were explored from various sources in the following study population: healthy non-medical personnel (147), healthy medical personnel (115), patients with...

Development Of A Quality Of Life Questionnaire: Sf-36 (Thai Version)(การพัฒนาแบบสอบถามคุณภาพชีวิต Sf-36 ฉบับภาษาไทย), Watcharee Leurmamkul, Paranee Meetam

The Thai Journal of Pharmaceutical Sciences

SF-36 is one of the most widely used instruments for the health-related quality of life assessment. It has been validated and studied in various groups of patients and general population. The main objective of this study was to develop a Thai version of ...

Once Daily Versus Twice Daily Dosing Of Gentamicin In Thai Neonates(การให้ยาเจนตามัยชินวันละครั้งเปรียบเทียบกับการให้ยาวันละสองครั..., Ampom Narongsanti, Uraiwan Chotigeat, Duangchit Panomvana Na Ayudhya

The Thai Journal of Pharmaceutical Sciences

The prospective, random ized trial of this study was conducted in 54 neonates w ith a gestation age of >34 weeks under 7 days of age at Queen Sirikit N ational Institute of Child H ealth from September to December 1998 to investigate the serum gentam ici...

Synthesis And Evaluation Of Chromone Derivatives As Potential Hiv-1 Protease Inhibitors(การสังเคราะห์และประเมินประสิทธิผลของอนุพันธ์โครโมนในการ..., Jirapom Ungwitayatorn, Chanpen Wiwat, Weerasak Samee

The Thai Journal of Pharmaceutical Sciences

A new class of non-peptide analogues in chromone series, were synthesized as potential HIV-1 protease inhibitors. The general structure of compounds consists of chromone nucleus with different substituents at position 2, 3, 7, and 8. The in vitro inhibit...

Establishing The Specifications Of Cassia Tom Linn. Seeds(การจัดทำข้อกำหนดเฉพาะของเมล็ดชุมเห็ดไทย), Nantana Sittichai, Sirichai Rrabesri, Ekamol Suthison

The Thai Journal of Pharmaceutical Sciences

The quality of Cassia tara Linn, seeds was investigated in order to set up specifications. The sample estimates at the significance level (a) of 0.05 with desired limits of error of 10 % and 20 % were determined. The 95 % confidence intervals for the sam...

Comparative Study Of Blood, Vitreous Humor And Urine Alcohol Concentrations In Thai Postmortem Traffic Accidental Victims(การศึกษาเปรียบเทียบระหว่างความเข้มข้นของแอลก..., Wichian Tungtananuwat, Somsong Lawanprasert, Niti Suwongthrom

The Thai Journal of Pharmaceutical Sciences

To utilize alcohol (referring to ethanol) concentrations in other biological specimens to estimate a blood alcohol concentration (BAC) when suitable postmortem blood sample is unavailable or contaminated, a good correlation between alcohol concentrations...

Professionalism And Motivation To Work In Pharmacy Externs(ลักษณะของผู้ประกอบวิชาชีพและแรงจูงใจในการทำงานของนักศึกษา เภสัชศา..., Sanguan Lerkiatbundit

The Thai Journal of Pharmaceutical Sciences

This study was designed to analyze and describe the change in professionalism as an outcome of the externship requirement in pharmacy students, and to determine the factors that can predict their motivation to work in various practice settings. Eighty-on...

Quality Evaluation Of Liquid Paraffin Emulsion Produced In Hospitals(การประเมินคุณภาพของยา Liquid Paraffin Emulsion ที่ผลิตใน โรงพยาบาล), Chantana Aromdee, Sumon Sakolchai, Unchalee Tattawasart, Thanee Tessiri, Yaowares Suwanphaiboon

The Thai Journal of Pharmaceutical Sciences

Liquid Paraffin Emulsion, an effective, mild and cheap feacal softener, is compounded and widely dispensed in hospitals. Twenty-nine samples were obtained from various sizes of hospitals and from every part of the country. Two samples were produced by a ...