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Pharmacology, Toxicology and Environmental Health Commons™
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- Estrogen receptor ligands (2)
- Expert systems (2)
- Air purity (1)
- Animal production and livestock (1)
- Binding affinity (1)
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- Environmental factors (1)
- Environmental impact (1)
- Human estrogen relative binding affinity (1)
- Indoor air quality (1)
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- Mammalian estrogen receptors (1)
- Pesticide (1)
- Pig farming (1)
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- Structure activity relationships (1)
- Structure activity relationships; (1)
- Waste treatment. (1)
- Water quality (1)
- Western Australia (1)
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Articles 1 - 5 of 5
Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Environmental Guidelines For New And Existing Piggeries, A Latto, John Noonan, R. J. Taylor
Environmental Guidelines For New And Existing Piggeries, A Latto, John Noonan, R. J. Taylor
Bulletins 4000 -
These guidelines apply to the management of Western Australia piggeries in Western Australia, including intensive Growing pigs under intensive conditions where the and extensive operations, straw-based housing and animals spend their entire life cycle indoors, is an combinations of these (otherwise referred to as semi- important part of the Western Australian and intensive housing).
Comparing The Epa Indoor Air Quality Personal Computer Model And Field Data, Arash Behravesh, Wilbur A. Spaul
Comparing The Epa Indoor Air Quality Personal Computer Model And Field Data, Arash Behravesh, Wilbur A. Spaul
RISK: Health, Safety & Environment (1990-2002)
The authors recommend caution in using an EPA model for reconstructing past exposure events as well as for predicting future exposures.
A Computationally Based Identification Algorithm For Estrogen Receptor Ligands: Part 2. Evaluation Of A Herα Binding Affinity Model, Steven P. Bradbury, O. G. Mekenyan, V. Kamenska, P. K. Schmieder, G. T. Ankley
A Computationally Based Identification Algorithm For Estrogen Receptor Ligands: Part 2. Evaluation Of A Herα Binding Affinity Model, Steven P. Bradbury, O. G. Mekenyan, V. Kamenska, P. K. Schmieder, G. T. Ankley
Steven P. Bradbury
The objective of this study was to evaluate the capability of an expert system described in the previous paper (S. Bradbury et al., Toxicol. Sci. 58, 253–269) to identify the potential for chemicals to act as ligands of mammalian estrogen receptors (ERs). The basis of the expert system was a structure activity relationship (SAR) model, based on relative binding affinity (RBA) values for steroidal and nonsteroidal chemicals derived from human ERa (hERa) competitive binding assays. The expert system enables categorization of chemicals into (RBA ranges of < 0.1, 0.1 to 1, 1 to 10, 10 to 100, and >150% relative to 17b-estradiol. In the current analysis, the algorithm was evaluated with respect …
A Computationally Based Identification Algorithm For Estrogen Receptor Ligands: Part 1. Predicting Herα Binding Affinity, Steven P. Bradbury, V. Kamenska, P. Schmieder, G. Ankley, O. Mekenyan
A Computationally Based Identification Algorithm For Estrogen Receptor Ligands: Part 1. Predicting Herα Binding Affinity, Steven P. Bradbury, V. Kamenska, P. Schmieder, G. Ankley, O. Mekenyan
Steven P. Bradbury
The common reactivity pattern (COREPA) approach is a 3-dimensional, quantitative structure activity relationship (3-D QSAR) technique that permits identification and quantification of specific global and local stereoelectronic characteristics associated with a chemical’s biological activity. It goes beyond conventional 3-D QSAR approaches by incorporating dynamic chemical conformational flexibility in ligand-receptor interactions. The approach provides flexibility in screening chemical data sets in that it helps establish criteria for identifying false positives and false negatives, and is not dependent upon a predetermined and specified toxicophore or an alignment of conformers to a lead compound. The algorithm was recently used to screen chemical data …
Effects Of Polychlorinated Biphenyl Exposure On Development And Sexual Differentiation In Ranid Tadpoles, Mary J. Rybitski
Effects Of Polychlorinated Biphenyl Exposure On Development And Sexual Differentiation In Ranid Tadpoles, Mary J. Rybitski
Dissertations, Theses, and Masters Projects
The effects of AroclorRTM1242 exposure on developing amphibians were examined by exposing southern leopard frogs, Rana sphenocephala, to a contaminated diet throughout the larval period. Treatment groups consisted of an untreated control, a solvent control, 17beta-estradiol, and three PCB doses (10, 100, and 1000 mug/g). PCB accumulation and biotransformation were examined. Effects of PCB exposure on metamorphosis and sexual differentiation were assessed. PCB accumulation was not statistically different between the egg masses. Levels of PCBs in the tissues differed in a dose related manner. Within treatments, body weight appeared to be the major factor correlated with PCB concentration. Congener patterns …