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Full-Text Articles in Pharmacology, Toxicology and Environmental Health

Megacity : A Reservoir Of Toxic Environmental Contaminants And Health Disease Burden, Omosehin Daniel Moyebi May 2022

Megacity : A Reservoir Of Toxic Environmental Contaminants And Health Disease Burden, Omosehin Daniel Moyebi

Legacy Theses & Dissertations (2009 - 2024)

Ambient air pollution is a global environmental problem of concern with more than 95% of the world population living in areas with unhealthy air. World Health Organization (WHO) in 2019 stated that air pollution is a principal environmental risk to human health with about 7 million premature air pollution-related deaths annually. Several epidemiological studies have linked morbidity due to cardiovascular diseases (CVDs) to ambient air pollution exposure, especially in North America and Europe. However, the effect of air pollution in Karachi, Pakistan is understudied, which is the case for many urban centers in the developing countries. Karachi is a megacity …


Environmental Factors And Human Health Interactions : Ultrafine Particles, Temperature Variability, And Proximity To Power Stations, Ian Ryan May 2022

Environmental Factors And Human Health Interactions : Ultrafine Particles, Temperature Variability, And Proximity To Power Stations, Ian Ryan

Legacy Theses & Dissertations (2009 - 2024)

Background: Air pollution leads to more than four million premature deaths worldwide and nearly 200,000 in the US each year. While there is extensive research relating PM2.5 to hospital visits for various health outcomes, there is relatively little research on ultrafine particles (UFPs), a particularly small and dangerous air pollutant. Another important exposure is temperature due to its association with dehydration, heat stress, and cardiovascular-related hospital admissions. However, relatively little research has been conducted on diurnal temperature range (DTR), or the range of temperature within a single day, which is an important indicator of climate change. Importantly, the interaction between …


Developing High-Resolution Meteorological Datasets To Assess The Short-Term Association Between Meteorological Factors And Green Space And Mental Disorders, Xinlei Deng Jan 2022

Developing High-Resolution Meteorological Datasets To Assess The Short-Term Association Between Meteorological Factors And Green Space And Mental Disorders, Xinlei Deng

Legacy Theses & Dissertations (2009 - 2024)

Global climate change is linked to the frequency and intensity of local climate extremes such as heatwaves, cold spells, and flooding. Scientific evidence indicates that heatwaves and higher ambient temperature could increase the risk of hospital admission and emergency department (ED) visits for mental disorders (MDs). On the other hand, urban green space is considered a way to reduce heat island effects and provide comfort for area residents. However, there still exist huge research gaps. Except for temperature, few studies have examined how other meteorological factors (relative humidity (RH), solar radiation (SR), heat index (HI), and rainfall) are associated with …


Disability In An American Indian Community : Prevalence, Distribution, And The Role Of Polychlorinated Biphenyls, Thoin F. Begum Jan 2022

Disability In An American Indian Community : Prevalence, Distribution, And The Role Of Polychlorinated Biphenyls, Thoin F. Begum

Legacy Theses & Dissertations (2009 - 2024)

Phthalates have been implicated as reproductive toxicants in animal models and in human populations. This study examined associations between potential exposure sources and urinary phthalate concentrations among couples undergoing infertility treatment. Women (n=56) and their male partners (n=43) undergoing in vitro fertilization (IVF) were enrolled in a prospective cohort investigation of environmental chemicals and IVF outcomes at an academic medical center. On the day of oocyte retrieval, participants provided urine samples and completed questionnaires detailing use of personal care products (PCPs), and consumption of medications, foods, and beverages in the preceding 24-hours. Urine was analyzed for MEP, MBP, MPP, MHxP, …


Disability In An American Indian Community : Prevalence, Distribution, And The Role Of Polychlorinated Biphenyls, Thoin Farzana Begum Jan 2022

Disability In An American Indian Community : Prevalence, Distribution, And The Role Of Polychlorinated Biphenyls, Thoin Farzana Begum

Legacy Theses & Dissertations (2009 - 2024)

The Akwesasne reservation along the St. Lawrence River has experienced significant exposure to several persistent organic pollutants due to rapid industrialization. The Aluminum Company of America, General Motors, and Reynolds Metals operated aluminum foundries that used polychlorinated biphenyls (PCBs) as hydraulic fluids, which contaminated the community environment, the soil, air and water, and community food sources with PCBs. We administered the World Health Organization Disability Assessment Schedule II (WHODAS II) to 119 Akwesasne Mohawk adults residing along the St. Lawrence River in New York. We used exploratory factor analysis to summarize the 36- items comprising the WHODAS II. The 7 …